Autoimmune liver disease and the enteric microbiome
The human enteric microbiome is highly complex and has more than 150 times more genes within it than its host. The host and the microbiome have a commensurate relationship that can evolve over time. The typically symbiotic relationship between the two can become pathogenic. The microbiome compositio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2018-05-01
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| Series: | AIMS Microbiology |
| Subjects: | |
| Online Access: | http://www.aimspress.com/microbiology/article/2013/fulltext.html |
| _version_ | 1818501149156704256 |
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| author | Kerri Glassner Eamonn MM Quigley Lissa Franco David W Victor III |
| author_facet | Kerri Glassner Eamonn MM Quigley Lissa Franco David W Victor III |
| author_sort | Kerri Glassner |
| collection | DOAJ |
| description | The human enteric microbiome is highly complex and has more than 150 times more genes within it than its host. The host and the microbiome have a commensurate relationship that can evolve over time. The typically symbiotic relationship between the two can become pathogenic. The microbiome composition in adults reflects their history of exposure to bacteria and environmental factors during early life, their genetic background, age, interactions with the immune system, geographical location, and, most especially, their diet. Similarly, these factors are thought to contribute to the development of autoimmune disease. It is possible that alterations in the intestinal microbiome could lead to liver disease. There is emerging data for the contribution of the microbiome in development of primary sclerosing cholangitis, primary biliary cholangitis, and autoimmune hepatitis; liver disorders associated with aberrant immune function in genetically susceptible individuals. |
| first_indexed | 2024-12-10T20:52:14Z |
| format | Article |
| id | doaj.art-a635ba3933c14493be1c9c249ec3b78d |
| institution | Directory Open Access Journal |
| issn | 2471-1888 |
| language | English |
| last_indexed | 2024-12-10T20:52:14Z |
| publishDate | 2018-05-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Microbiology |
| spelling | doaj.art-a635ba3933c14493be1c9c249ec3b78d2022-12-22T01:34:04ZengAIMS PressAIMS Microbiology2471-18882018-05-014233434610.3934/microbiol.2018.2.334microbiol-04-02-334Autoimmune liver disease and the enteric microbiomeKerri Glassner0Eamonn MM Quigley1Lissa Franco2David W Victor IIILynda K and David M Underwood Center for Digestive Disorders, Division of Gastroenterology and Hepatology, Houston Methodist Hospital, Weill Cornell Medical College, 6550 Fannin Street, SM 1201, Houston, TX 77030, USALynda K and David M Underwood Center for Digestive Disorders, Division of Gastroenterology and Hepatology, Houston Methodist Hospital, Weill Cornell Medical College, 6550 Fannin Street, SM 1201, Houston, TX 77030, USALynda K and David M Underwood Center for Digestive Disorders, Division of Gastroenterology and Hepatology, Houston Methodist Hospital, Weill Cornell Medical College, 6550 Fannin Street, SM 1201, Houston, TX 77030, USAThe human enteric microbiome is highly complex and has more than 150 times more genes within it than its host. The host and the microbiome have a commensurate relationship that can evolve over time. The typically symbiotic relationship between the two can become pathogenic. The microbiome composition in adults reflects their history of exposure to bacteria and environmental factors during early life, their genetic background, age, interactions with the immune system, geographical location, and, most especially, their diet. Similarly, these factors are thought to contribute to the development of autoimmune disease. It is possible that alterations in the intestinal microbiome could lead to liver disease. There is emerging data for the contribution of the microbiome in development of primary sclerosing cholangitis, primary biliary cholangitis, and autoimmune hepatitis; liver disorders associated with aberrant immune function in genetically susceptible individuals.http://www.aimspress.com/microbiology/article/2013/fulltext.htmlprimary sclerosing cholangitisprimary biliary cholangitisautoimmune hepatitismicrobiomePSCPBC |
| spellingShingle | Kerri Glassner Eamonn MM Quigley Lissa Franco David W Victor III Autoimmune liver disease and the enteric microbiome AIMS Microbiology primary sclerosing cholangitis primary biliary cholangitis autoimmune hepatitis microbiome PSC PBC |
| title | Autoimmune liver disease and the enteric microbiome |
| title_full | Autoimmune liver disease and the enteric microbiome |
| title_fullStr | Autoimmune liver disease and the enteric microbiome |
| title_full_unstemmed | Autoimmune liver disease and the enteric microbiome |
| title_short | Autoimmune liver disease and the enteric microbiome |
| title_sort | autoimmune liver disease and the enteric microbiome |
| topic | primary sclerosing cholangitis primary biliary cholangitis autoimmune hepatitis microbiome PSC PBC |
| url | http://www.aimspress.com/microbiology/article/2013/fulltext.html |
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