Prognostic factors of epilepsy in patients with neonatal seizures history
Background Seizures in neonates are often associated with neurological disorders in early life, including epilepsy. Several possible prognostic factors may influence the development of epilepsy in these patients. Objective To evaluate prognostic factors that may influence the occurrence of epilepsy...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2013-08-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/285 |
| Summary: | Background Seizures in neonates are often associated with
neurological disorders in early life, including epilepsy. Several
possible prognostic factors may influence the development of
epilepsy in these patients.
Objective To evaluate prognostic factors that may influence the
occurrence of epilepsy in the first two years of life in patients with
a history of neonatal seizures.
Methods We performed a cohort retrospective study on patients
with neonatal se izures in Sardjito Hospital during 2004-2009.
Prognostic factors observed were gender, family history of
epilepsy, neonatal hypoglycemia, assisted labor, hypoxic ischemic
encephalopathy, preterm infant delivery, and epileptic state.
Results Hypoxic ischemic encephalopathy and epileptic state
increased the risk of epilepsy (HR 5.8; 95%CI 1.63 to 20.43 and
HR 6.3; 95%CI 2 .0 to 19. 70, respectively). Assisted labor, preterm
delivery, neonatal hypoglycemia, family history of epilepsy, and
gender did not increase the risk of epilepsy in the first two years
of life.
Conclusion Hypoxic ischemic encephalopathy and epileptic state
in neonates presenting with seizures are the prognostic factors to
be epileptic children during the first two years of life. |
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| ISSN: | 0030-9311 2338-476X |