Vitamin D deficiency promoting non-24 h sleep–wake disorder: a case report
We report a case of an emmetropic woman with excessive daytime sleepiness in alternation with insomnia consistent with the diagnosis criteria of a non-24 h sleep–wake disorder. After being refractory to the usual non-pharmacologic and pharmacologic treatment, we detected a deficiency of vitamin B12,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1141835/full |
| _version_ | 1797845553334190080 |
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| author | Richard Friedrich Radlberger Alexander Baden Kunz |
| author_facet | Richard Friedrich Radlberger Alexander Baden Kunz |
| author_sort | Richard Friedrich Radlberger |
| collection | DOAJ |
| description | We report a case of an emmetropic woman with excessive daytime sleepiness in alternation with insomnia consistent with the diagnosis criteria of a non-24 h sleep–wake disorder. After being refractory to the usual non-pharmacologic and pharmacologic treatment, we detected a deficiency of vitamin B12, vitamin D3, and folic acid. Substitution of these treatments led to a return of a 24 h sleep–wake rhythm though this remained independent from the external light–dark cycle. The question arises whether the vitamin D deficiency could be regarded as an epiphenomenon or whether there is an up-to-date unknown connection to the inner zeitgeber. |
| first_indexed | 2024-04-09T17:40:53Z |
| format | Article |
| id | doaj.art-a63836ed02eb4742a45b045f5cf4d919 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T17:40:53Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-a63836ed02eb4742a45b045f5cf4d9192023-04-17T05:27:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.11418351141835Vitamin D deficiency promoting non-24 h sleep–wake disorder: a case reportRichard Friedrich RadlbergerAlexander Baden KunzWe report a case of an emmetropic woman with excessive daytime sleepiness in alternation with insomnia consistent with the diagnosis criteria of a non-24 h sleep–wake disorder. After being refractory to the usual non-pharmacologic and pharmacologic treatment, we detected a deficiency of vitamin B12, vitamin D3, and folic acid. Substitution of these treatments led to a return of a 24 h sleep–wake rhythm though this remained independent from the external light–dark cycle. The question arises whether the vitamin D deficiency could be regarded as an epiphenomenon or whether there is an up-to-date unknown connection to the inner zeitgeber.https://www.frontiersin.org/articles/10.3389/fneur.2023.1141835/fullvitamin Dvitamin B and folic acidnon 24 h sleep–wake disorderseasonal affective disorder (SAD)case report |
| spellingShingle | Richard Friedrich Radlberger Alexander Baden Kunz Vitamin D deficiency promoting non-24 h sleep–wake disorder: a case report Frontiers in Neurology vitamin D vitamin B and folic acid non 24 h sleep–wake disorder seasonal affective disorder (SAD) case report |
| title | Vitamin D deficiency promoting non-24 h sleep–wake disorder: a case report |
| title_full | Vitamin D deficiency promoting non-24 h sleep–wake disorder: a case report |
| title_fullStr | Vitamin D deficiency promoting non-24 h sleep–wake disorder: a case report |
| title_full_unstemmed | Vitamin D deficiency promoting non-24 h sleep–wake disorder: a case report |
| title_short | Vitamin D deficiency promoting non-24 h sleep–wake disorder: a case report |
| title_sort | vitamin d deficiency promoting non 24 h sleep wake disorder a case report |
| topic | vitamin D vitamin B and folic acid non 24 h sleep–wake disorder seasonal affective disorder (SAD) case report |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1141835/full |
| work_keys_str_mv | AT richardfriedrichradlberger vitaminddeficiencypromotingnon24hsleepwakedisorderacasereport AT alexanderbadenkunz vitaminddeficiencypromotingnon24hsleepwakedisorderacasereport |