In Silico Investigations of Multi-Drug Adaptive Therapy Protocols

In Silico Investigations of Multi-Drug Adaptive Therapy Protocols

The standard of care for cancer patients aims to eradicate the tumor by killing the maximum number of cancer cells using the maximum tolerated dose (MTD) of a drug. MTD causes significant toxicity and selects for resistant cells, eventually making the tumor refractory to treatment. Adaptive therapy...

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Bibliographic Details
Main Authors: Daniel S. Thomas, Luis H. Cisneros, Alexander R. A. Anderson, Carlo C. Maley
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
adaptive therapy
cancer
drug resistance
dose modulation
evolution
agent-based model
Online Access:https://www.mdpi.com/2072-6694/14/11/2699

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