Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers
Phenolic compounds in peanuts may moderate inflammation and endothelial function. Thus, the aim of this study was to evaluate the association of urinary phenolic metabolites (UPMs) with vascular biomarkers after peanut product consumption. A three-arm parallel-group randomized controlled trial was c...
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MDPI AG
2023-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/3/698 |
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| author | Isabella Parilli-Moser Inés Domínguez-López Anna Vallverdú-Queralt Sara Hurtado-Barroso Rosa M. Lamuela-Raventós |
| author_facet | Isabella Parilli-Moser Inés Domínguez-López Anna Vallverdú-Queralt Sara Hurtado-Barroso Rosa M. Lamuela-Raventós |
| author_sort | Isabella Parilli-Moser |
| collection | DOAJ |
| description | Phenolic compounds in peanuts may moderate inflammation and endothelial function. Thus, the aim of this study was to evaluate the association of urinary phenolic metabolites (UPMs) with vascular biomarkers after peanut product consumption. A three-arm parallel-group randomized controlled trial was conducted in 63 healthy young adults who consumed 25 g/day of skin roasted peanuts (SRP), 32 g/day of peanut butter (PB), or 32 g/day of a control butter for six months. UPMs were analyzed by liquid chromatography coupled to mass spectrometry. Additionally, urinary eicosanoids, prostacyclin I2 (PGI<sub>2</sub>), and thromboxane A2 (TXA<sub>2</sub>) were determined using two competitive enzyme-linked immunosorbent assay kits. Consumers of SRP and PB presented significantly higher excretion of UPMs (enterodiol glucuronide (<i>p</i> = 0.018 and <i>p</i> = 0.031), 3-hydroxybenzoic acid (<i>p</i> = 0.002 and <i>p</i> < 0.001), vanillic acid sulfate (<i>p</i> = 0.048 and <i>p</i> = 0.006), <i>p</i>-coumaric acid (<i>p</i> = 0.046 and <i>p</i> = 0.016), coumaric acid glucuronide I (<i>p</i> = 0.001 and <i>p</i> = 0.030) and II (<i>p</i> = 0.003 and <i>p</i> = 0.036), and isoferulic acid (<i>p</i> = 0.013 and <i>p</i> = 0.015) in comparison with the control group. An improvement in PGI<sub>2</sub> (<i>p</i> = 0.037) levels and the TXA<sub>2</sub>:PGI<sub>2</sub> ratio (<i>p</i> = 0.008) was also observed after the peanut interventions compared to the control. Interestingly, UPMs with significantly higher post-intervention levels were correlated with an improvement in vascular biomarkers, lower TXA<sub>2</sub> (r from −0.25 to −0.48, <i>p</i> < 0.050) and TXA<sub>2</sub>:PGI<sub>2</sub> ratio (r from −0.25 to −0.43, <i>p</i> < 0.050) and higher PGI<sub>2</sub> (r from 0.24 to 0.36, <i>p</i> < 0.050). These findings suggest that the UPMs with higher excretion after peanut product consumption could have a positive impact on vascular health. |
| first_indexed | 2024-03-11T07:00:48Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-11T07:00:48Z |
| publishDate | 2023-03-01 |
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| series | Antioxidants |
| spelling | doaj.art-a63a08e4a2e240959181e56865b53be42023-11-17T09:18:31ZengMDPI AGAntioxidants2076-39212023-03-0112369810.3390/antiox12030698Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health BiomarkersIsabella Parilli-Moser0Inés Domínguez-López1Anna Vallverdú-Queralt2Sara Hurtado-Barroso3Rosa M. Lamuela-Raventós4Department of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences XIA, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08028 Barcelona, SpainDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences XIA, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08028 Barcelona, SpainDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences XIA, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08028 Barcelona, SpainDepartment of Medicine, School of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, SpainDepartment of Nutrition, Food Sciences and Gastronomy, School of Pharmacy and Food Sciences XIA, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08028 Barcelona, SpainPhenolic compounds in peanuts may moderate inflammation and endothelial function. Thus, the aim of this study was to evaluate the association of urinary phenolic metabolites (UPMs) with vascular biomarkers after peanut product consumption. A three-arm parallel-group randomized controlled trial was conducted in 63 healthy young adults who consumed 25 g/day of skin roasted peanuts (SRP), 32 g/day of peanut butter (PB), or 32 g/day of a control butter for six months. UPMs were analyzed by liquid chromatography coupled to mass spectrometry. Additionally, urinary eicosanoids, prostacyclin I2 (PGI<sub>2</sub>), and thromboxane A2 (TXA<sub>2</sub>) were determined using two competitive enzyme-linked immunosorbent assay kits. Consumers of SRP and PB presented significantly higher excretion of UPMs (enterodiol glucuronide (<i>p</i> = 0.018 and <i>p</i> = 0.031), 3-hydroxybenzoic acid (<i>p</i> = 0.002 and <i>p</i> < 0.001), vanillic acid sulfate (<i>p</i> = 0.048 and <i>p</i> = 0.006), <i>p</i>-coumaric acid (<i>p</i> = 0.046 and <i>p</i> = 0.016), coumaric acid glucuronide I (<i>p</i> = 0.001 and <i>p</i> = 0.030) and II (<i>p</i> = 0.003 and <i>p</i> = 0.036), and isoferulic acid (<i>p</i> = 0.013 and <i>p</i> = 0.015) in comparison with the control group. An improvement in PGI<sub>2</sub> (<i>p</i> = 0.037) levels and the TXA<sub>2</sub>:PGI<sub>2</sub> ratio (<i>p</i> = 0.008) was also observed after the peanut interventions compared to the control. Interestingly, UPMs with significantly higher post-intervention levels were correlated with an improvement in vascular biomarkers, lower TXA<sub>2</sub> (r from −0.25 to −0.48, <i>p</i> < 0.050) and TXA<sub>2</sub>:PGI<sub>2</sub> ratio (r from −0.25 to −0.43, <i>p</i> < 0.050) and higher PGI<sub>2</sub> (r from 0.24 to 0.36, <i>p</i> < 0.050). These findings suggest that the UPMs with higher excretion after peanut product consumption could have a positive impact on vascular health.https://www.mdpi.com/2076-3921/12/3/698antioxidantantiplateletantithromboticeicosanoidspolyphenolsvascular health |
| spellingShingle | Isabella Parilli-Moser Inés Domínguez-López Anna Vallverdú-Queralt Sara Hurtado-Barroso Rosa M. Lamuela-Raventós Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers Antioxidants antioxidant antiplatelet antithrombotic eicosanoids polyphenols vascular health |
| title | Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers |
| title_full | Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers |
| title_fullStr | Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers |
| title_full_unstemmed | Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers |
| title_short | Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers |
| title_sort | urinary phenolic metabolites associated with peanut consumption may have a beneficial impact on vascular health biomarkers |
| topic | antioxidant antiplatelet antithrombotic eicosanoids polyphenols vascular health |
| url | https://www.mdpi.com/2076-3921/12/3/698 |
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