Theophylline attenuates bleomycin-induced oxidative stress in rats: The role of IL-6, NF-κB, and antioxidant enzymes

Theophylline attenuates bleomycin-induced oxidative stress in rats: The role of IL-6, NF-κB, and antioxidant enzymes

Abstract The purpose of this study was to evaluate the antifibrotic and antioxidant roles of theophylline (Theo), a bioactive compound, in bleomycin (BLM)-induced pulmonary fibrosis in Wistar albino rats. Assigned into 4 groups were 32 Wistar albino rats, comprising the control group (administered 0...

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Bibliographic Details
Main Authors: Suat Ekin, Serkan Yildirim, Mahire Bayramoglu Akkoyun, Hasya Nazli Gok, Okan Arihan, Gokhan Oto, Turan Akkoyun, Yildiray Basbugan, Sinem Aslan
Format: Article
Language:English
Published: Universidade de São Paulo 2022-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Theophylline. Bleomycin. IL-6
NF-κB. Antioxidant enzymes
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100788&tlng=en

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