Complement-dependent cytotoxicity of human autoantibodies against myelin oligodendrocyte glycoprotein

Complement-dependent cytotoxicity of human autoantibodies against myelin oligodendrocyte glycoprotein

BackgroundThe autoantibody to myelin oligodendrocyte glycoprotein (MOG), a component of the central nervous system myelin, has been identified in a subset of demyelinating diseases. However, there is no convincing evidence to support the direct pathogenic contribution of this autoantibody.ObjectiveT...

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Bibliographic Details
Main Authors: Kuniko Kohyama, Hiroya Nishida, Kimihiko Kaneko, Tatsuro Misu, Ichiro Nakashima, Hiroshi Sakuma
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Neuroscience
Subjects:
myelin oligodendrocyte glycoprotein
autoantibody
acquired demyelinating syndromes
cytotoxicity
complement
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1014071/full

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