Single-cell transcriptomics combined with proteomics of intrathecal IgG reveal transcriptional heterogeneity of oligoclonal IgG-secreting cells in multiple sclerosis

Single-cell transcriptomics combined with proteomics of intrathecal IgG reveal transcriptional heterogeneity of oligoclonal IgG-secreting cells in multiple sclerosis

The phenotypes of B lineage cells that produce oligoclonal IgG in multiple sclerosis have not been unequivocally determined. Here, we utilized single-cell RNA-seq data of intrathecal B lineage cells in combination with mass spectrometry of intrathecally synthesized IgG to identify its cellular sourc...

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Bibliographic Details
Main Authors: Justyna Polak, Johanna H. Wagnerberger, Silje Bøen Torsetnes, Ida Lindeman, Rune A. Aa. Høglund, Frode Vartdal, Ludvig M. Sollid, Andreas Lossius
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
multiple sclerosis
B cells
plasmablasts
oligoclonal bands (OCB)
IgG
cerebrospinal fluid
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1189709/full

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