In Vitro and In Vivo evaluation of montmorillonite for paraquat poisoning
Abstract Evaluation of montmorillonite for paraquat by in vitro and in vivo test. In vitro test were evaluated by a batch test, taking the paraquat concentration, adsorbents, reaction environment and time as indices, the absorption rate was screened by orthogonal design. In vivo test was executed wi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2023-01-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100310&tlng=en |
| _version_ | 1797951328642662400 |
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| author | Xiang Guo Wei Guo Tiandi Li Fen Liu Jinpeng Zhou Meiqiong Guo |
| author_facet | Xiang Guo Wei Guo Tiandi Li Fen Liu Jinpeng Zhou Meiqiong Guo |
| author_sort | Xiang Guo |
| collection | DOAJ |
| description | Abstract Evaluation of montmorillonite for paraquat by in vitro and in vivo test. In vitro test were evaluated by a batch test, taking the paraquat concentration, adsorbents, reaction environment and time as indices, the absorption rate was screened by orthogonal design. In vivo test was executed with rabbits. Group 1: 4 rabbits dosed with montmorillonite. Group 2: 8 rabbits dosed with 200 mg/kg paraquat. Group 3: 6 rabbits dosed with 200 mg/kg paraquat then gavage with montmorillonite 5 min later. Group 4: 6 rabbits dosed with 200 mg/kg paraquat then gavage with montmorillonite 30 min later. Blood paraquat concentration, serum cytokines, blood gas analysis and histopathology of lung were implemented. In vitro test found that all the four factors influence the absorption rate of paraquat (P < 0.05). In vitro test found that oral montmorillonite could change toxicokinetics parameters of paraquat (P < 0.05); decrease raised serum TGF-β1 and HMGB1 (P < 0.05) and alleviate the histopathology damage of lung. Montmorillonite might exert its protective effects on paraquat induced damage. |
| first_indexed | 2024-04-10T22:28:49Z |
| format | Article |
| id | doaj.art-a63cbfe64ea94e6ca6e97b6ea7654086 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-10T22:28:49Z |
| publishDate | 2023-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-a63cbfe64ea94e6ca6e97b6ea76540862023-01-17T07:34:51ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902023-01-015810.1590/s2175-97902022e21600In Vitro and In Vivo evaluation of montmorillonite for paraquat poisoningXiang Guohttps://orcid.org/0000-0001-9794-7871Wei Guohttps://orcid.org/0000-0002-5334-3221Tiandi Lihttps://orcid.org/0000-0001-5427-0610Fen Liuhttps://orcid.org/0000-0001-6600-1055Jinpeng Zhouhttps://orcid.org/0000-0002-1396-8665Meiqiong Guohttps://orcid.org/0000-0001-5191-8434Abstract Evaluation of montmorillonite for paraquat by in vitro and in vivo test. In vitro test were evaluated by a batch test, taking the paraquat concentration, adsorbents, reaction environment and time as indices, the absorption rate was screened by orthogonal design. In vivo test was executed with rabbits. Group 1: 4 rabbits dosed with montmorillonite. Group 2: 8 rabbits dosed with 200 mg/kg paraquat. Group 3: 6 rabbits dosed with 200 mg/kg paraquat then gavage with montmorillonite 5 min later. Group 4: 6 rabbits dosed with 200 mg/kg paraquat then gavage with montmorillonite 30 min later. Blood paraquat concentration, serum cytokines, blood gas analysis and histopathology of lung were implemented. In vitro test found that all the four factors influence the absorption rate of paraquat (P < 0.05). In vitro test found that oral montmorillonite could change toxicokinetics parameters of paraquat (P < 0.05); decrease raised serum TGF-β1 and HMGB1 (P < 0.05) and alleviate the histopathology damage of lung. Montmorillonite might exert its protective effects on paraquat induced damage.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100310&tlng=enParaquatMontmorilloniteToxicokineticsHistopathologyIn vivoIn vitro |
| spellingShingle | Xiang Guo Wei Guo Tiandi Li Fen Liu Jinpeng Zhou Meiqiong Guo In Vitro and In Vivo evaluation of montmorillonite for paraquat poisoning Brazilian Journal of Pharmaceutical Sciences Paraquat Montmorillonite Toxicokinetics Histopathology In vivo In vitro |
| title | In Vitro and In Vivo evaluation of montmorillonite for paraquat poisoning |
| title_full | In Vitro and In Vivo evaluation of montmorillonite for paraquat poisoning |
| title_fullStr | In Vitro and In Vivo evaluation of montmorillonite for paraquat poisoning |
| title_full_unstemmed | In Vitro and In Vivo evaluation of montmorillonite for paraquat poisoning |
| title_short | In Vitro and In Vivo evaluation of montmorillonite for paraquat poisoning |
| title_sort | in vitro and in vivo evaluation of montmorillonite for paraquat poisoning |
| topic | Paraquat Montmorillonite Toxicokinetics Histopathology In vivo In vitro |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100310&tlng=en |
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