Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts
Pneumocystis jirovecii is a fungus that can cause life-threatening pneumonia in immunocompromised patients. Here, the authors sequence the genomes of P. jirovecii and two other Pneumocystisspecies, and show the unexpected absence of chitin (a near universal fungal cell wall component).
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10740 |
| _version_ | 1818342571387125760 |
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| author | Liang Ma Zehua Chen Da Wei Huang Geetha Kutty Mayumi Ishihara Honghui Wang Amr Abouelleil Lisa Bishop Emma Davey Rebecca Deng Xilong Deng Lin Fan Giovanna Fantoni Michael Fitzgerald Emile Gogineni Jonathan M. Goldberg Grace Handley Xiaojun Hu Charles Huber Xiaoli Jiao Kristine Jones Joshua Z. Levin Yueqin Liu Pendexter Macdonald Alexandre Melnikov Castle Raley Monica Sassi Brad T. Sherman Xiaohong Song Sean Sykes Bao Tran Laura Walsh Yun Xia Jun Yang Sarah Young Qiandong Zeng Xin Zheng Robert Stephens Chad Nusbaum Bruce W. Birren Parastoo Azadi Richard A. Lempicki Christina A. Cuomo Joseph A. Kovacs |
| author_facet | Liang Ma Zehua Chen Da Wei Huang Geetha Kutty Mayumi Ishihara Honghui Wang Amr Abouelleil Lisa Bishop Emma Davey Rebecca Deng Xilong Deng Lin Fan Giovanna Fantoni Michael Fitzgerald Emile Gogineni Jonathan M. Goldberg Grace Handley Xiaojun Hu Charles Huber Xiaoli Jiao Kristine Jones Joshua Z. Levin Yueqin Liu Pendexter Macdonald Alexandre Melnikov Castle Raley Monica Sassi Brad T. Sherman Xiaohong Song Sean Sykes Bao Tran Laura Walsh Yun Xia Jun Yang Sarah Young Qiandong Zeng Xin Zheng Robert Stephens Chad Nusbaum Bruce W. Birren Parastoo Azadi Richard A. Lempicki Christina A. Cuomo Joseph A. Kovacs |
| author_sort | Liang Ma |
| collection | DOAJ |
| description | Pneumocystis jirovecii is a fungus that can cause life-threatening pneumonia in immunocompromised patients. Here, the authors sequence the genomes of P. jirovecii and two other Pneumocystisspecies, and show the unexpected absence of chitin (a near universal fungal cell wall component). |
| first_indexed | 2024-12-13T16:16:48Z |
| format | Article |
| id | doaj.art-a63cc72f702b47298d73bf4e878df92d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:16:48Z |
| publishDate | 2016-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a63cc72f702b47298d73bf4e878df92d2022-12-21T23:38:49ZengNature PortfolioNature Communications2041-17232016-02-017111410.1038/ncomms10740Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hostsLiang Ma0Zehua Chen1Da Wei Huang2Geetha Kutty3Mayumi Ishihara4Honghui Wang5Amr Abouelleil6Lisa Bishop7Emma Davey8Rebecca Deng9Xilong Deng10Lin Fan11Giovanna Fantoni12Michael Fitzgerald13Emile Gogineni14Jonathan M. Goldberg15Grace Handley16Xiaojun Hu17Charles Huber18Xiaoli Jiao19Kristine Jones20Joshua Z. Levin21Yueqin Liu22Pendexter Macdonald23Alexandre Melnikov24Castle Raley25Monica Sassi26Brad T. Sherman27Xiaohong Song28Sean Sykes29Bao Tran30Laura Walsh31Yun Xia32Jun Yang33Sarah Young34Qiandong Zeng35Xin Zheng36Robert Stephens37Chad Nusbaum38Bruce W. Birren39Parastoo Azadi40Richard A. Lempicki41Christina A. Cuomo42Joseph A. Kovacs43Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USAGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyLeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USAComplex Carbohydrate Research Center, University of GeorgiaCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USAGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USACritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USACritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USACritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USAGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USAGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USAGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USALeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USALeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchLeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USAGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyLeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USALeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USAGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyLeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USACritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USALeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyLeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchLeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyComplex Carbohydrate Research Center, University of GeorgiaLeidos BioMedical Research, Inc., Frederick National Laboratory for Cancer ResearchGenome Sequencing and Analysis Program, Broad Institute of Harvard and Massachusetts Institute of TechnologyCritical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Building 10, Room 2C145, 10 Center Drive, Bethesda, Maryland 20892, USAPneumocystis jirovecii is a fungus that can cause life-threatening pneumonia in immunocompromised patients. Here, the authors sequence the genomes of P. jirovecii and two other Pneumocystisspecies, and show the unexpected absence of chitin (a near universal fungal cell wall component).https://doi.org/10.1038/ncomms10740 |
| spellingShingle | Liang Ma Zehua Chen Da Wei Huang Geetha Kutty Mayumi Ishihara Honghui Wang Amr Abouelleil Lisa Bishop Emma Davey Rebecca Deng Xilong Deng Lin Fan Giovanna Fantoni Michael Fitzgerald Emile Gogineni Jonathan M. Goldberg Grace Handley Xiaojun Hu Charles Huber Xiaoli Jiao Kristine Jones Joshua Z. Levin Yueqin Liu Pendexter Macdonald Alexandre Melnikov Castle Raley Monica Sassi Brad T. Sherman Xiaohong Song Sean Sykes Bao Tran Laura Walsh Yun Xia Jun Yang Sarah Young Qiandong Zeng Xin Zheng Robert Stephens Chad Nusbaum Bruce W. Birren Parastoo Azadi Richard A. Lempicki Christina A. Cuomo Joseph A. Kovacs Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts Nature Communications |
| title | Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts |
| title_full | Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts |
| title_fullStr | Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts |
| title_full_unstemmed | Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts |
| title_short | Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts |
| title_sort | genome analysis of three pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts |
| url | https://doi.org/10.1038/ncomms10740 |
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