Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case–Control Study
BackgroundA possible relationship between oral lichen planus (OLP) and thyroid disease has received attention in recent years.ObjectiveThis study aimed to evaluate the correlation between OLP and thyroid diseases in Chinese ethnic patients.Methods192 OLP patients, 123 patients with oral lichenoid le...
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| Format: | Article |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2018.00330/full |
| _version_ | 1828299207013826560 |
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| author | Tingting Zhou Dan Li Qianming Chen Hong Hua Chunlei Li |
| author_facet | Tingting Zhou Dan Li Qianming Chen Hong Hua Chunlei Li |
| author_sort | Tingting Zhou |
| collection | DOAJ |
| description | BackgroundA possible relationship between oral lichen planus (OLP) and thyroid disease has received attention in recent years.ObjectiveThis study aimed to evaluate the correlation between OLP and thyroid diseases in Chinese ethnic patients.Methods192 OLP patients, 123 patients with oral lichenoid lesions (OLLs), and 162 controls were recruited in this case–control study. All participants received screening for thyroid function and underwent ultrasound. Sex and age of the patients in the three groups were matched. The prevalence of thyroid diseases in the subjects was analyzed. Using logistic regression, the odds ratio (OR) with 95% confidence intervals was appraised for associations between OLP, OLL, and different types of thyroid diseases [Hashimoto’s thyroiditis (HT), hypothyroidism, and thyroid nodule].ResultsThe prevalence of thyroid diseases in the OLP group (72.4%) and OLL group (68.3%) was higher than the control group (49.4%) with statistical significance. The OR of HT was 3.16 (1.87–5.33) for OLP, 2.09 (1.18–3.70) for OLL, while the OR of thyroid nodule was 2.31 (1.30–4.09) for OLP.ConclusionOur study suggested a close relationship between OLP/OLL and HT and thyroid nodule in a Chinese population. The possible mechanism behind this association warrants further investigation. |
| first_indexed | 2024-04-13T12:52:18Z |
| format | Article |
| id | doaj.art-a63dd135ae844d90bc4f861ca6f56ddd |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T12:52:18Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a63dd135ae844d90bc4f861ca6f56ddd2022-12-22T02:46:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-06-01910.3389/fendo.2018.00330363311Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case–Control StudyTingting Zhou0Dan Li1Qianming Chen2Hong Hua3Chunlei Li4Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, ChinaDepartment of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, ChinaDepartment of Oral Medicine, West China School of Stomatology, SiChuan University, Chengdu, ChinaDepartment of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, ChinaDepartment of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, ChinaBackgroundA possible relationship between oral lichen planus (OLP) and thyroid disease has received attention in recent years.ObjectiveThis study aimed to evaluate the correlation between OLP and thyroid diseases in Chinese ethnic patients.Methods192 OLP patients, 123 patients with oral lichenoid lesions (OLLs), and 162 controls were recruited in this case–control study. All participants received screening for thyroid function and underwent ultrasound. Sex and age of the patients in the three groups were matched. The prevalence of thyroid diseases in the subjects was analyzed. Using logistic regression, the odds ratio (OR) with 95% confidence intervals was appraised for associations between OLP, OLL, and different types of thyroid diseases [Hashimoto’s thyroiditis (HT), hypothyroidism, and thyroid nodule].ResultsThe prevalence of thyroid diseases in the OLP group (72.4%) and OLL group (68.3%) was higher than the control group (49.4%) with statistical significance. The OR of HT was 3.16 (1.87–5.33) for OLP, 2.09 (1.18–3.70) for OLL, while the OR of thyroid nodule was 2.31 (1.30–4.09) for OLP.ConclusionOur study suggested a close relationship between OLP/OLL and HT and thyroid nodule in a Chinese population. The possible mechanism behind this association warrants further investigation.https://www.frontiersin.org/article/10.3389/fendo.2018.00330/fulloral lichen planusoral lichenoid lesionHashimoto’s thyroiditishypothyroidismthyroid nodulemolecular mimicry |
| spellingShingle | Tingting Zhou Dan Li Qianming Chen Hong Hua Chunlei Li Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case–Control Study Frontiers in Endocrinology oral lichen planus oral lichenoid lesion Hashimoto’s thyroiditis hypothyroidism thyroid nodule molecular mimicry |
| title | Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case–Control Study |
| title_full | Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case–Control Study |
| title_fullStr | Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case–Control Study |
| title_full_unstemmed | Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case–Control Study |
| title_short | Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case–Control Study |
| title_sort | correlation between oral lichen planus and thyroid disease in china a case control study |
| topic | oral lichen planus oral lichenoid lesion Hashimoto’s thyroiditis hypothyroidism thyroid nodule molecular mimicry |
| url | https://www.frontiersin.org/article/10.3389/fendo.2018.00330/full |
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