The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease
The contractile activity, high oxygen consumption and metabolic rate of skeletal muscle cause it to continuously produce moderate levels of oxidant species, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS). Under normal physiological conditions, there is a dynamic balance be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/4/755 |
| _version_ | 1797437109940781056 |
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| author | Di Lian Ming-Ming Chen Hanyu Wu Shoulong Deng Xiaoxiang Hu |
| author_facet | Di Lian Ming-Ming Chen Hanyu Wu Shoulong Deng Xiaoxiang Hu |
| author_sort | Di Lian |
| collection | DOAJ |
| description | The contractile activity, high oxygen consumption and metabolic rate of skeletal muscle cause it to continuously produce moderate levels of oxidant species, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS). Under normal physiological conditions, there is a dynamic balance between the production and elimination of ROS/RNS. However, when the oxidation products exceed the antioxidant defense capacity, the body enters a state of oxidative stress. Myogenesis is an important process to maintain muscle homeostasis and the physiological function of skeletal muscle. Accumulating evidence suggests that oxidative stress plays a key role in myogenesis and skeletal muscle physiology and pathology. In this review, we summarize the sources of reactive oxygen species in skeletal muscle and the causes of oxidative stress and analyze the key role of oxidative stress in myogenesis. Then, we discuss the relationship between oxidative stress and muscle homeostasis and physiopathology. This work systematically summarizes the role of oxidative stress in myogenesis and muscle diseases and provides targets for subsequent antioxidant therapy and repair of inflammatory damage in noninflammatory muscle diseases. |
| first_indexed | 2024-03-09T11:14:14Z |
| format | Article |
| id | doaj.art-a63e115290bd477b9337e75a32d820fc |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T11:14:14Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-a63e115290bd477b9337e75a32d820fc2023-12-01T00:36:22ZengMDPI AGAntioxidants2076-39212022-04-0111475510.3390/antiox11040755The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle DiseaseDi Lian0Ming-Ming Chen1Hanyu Wu2Shoulong Deng3Xiaoxiang Hu4State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, ChinaBeijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, ChinaNHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, ChinaState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, ChinaThe contractile activity, high oxygen consumption and metabolic rate of skeletal muscle cause it to continuously produce moderate levels of oxidant species, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS). Under normal physiological conditions, there is a dynamic balance between the production and elimination of ROS/RNS. However, when the oxidation products exceed the antioxidant defense capacity, the body enters a state of oxidative stress. Myogenesis is an important process to maintain muscle homeostasis and the physiological function of skeletal muscle. Accumulating evidence suggests that oxidative stress plays a key role in myogenesis and skeletal muscle physiology and pathology. In this review, we summarize the sources of reactive oxygen species in skeletal muscle and the causes of oxidative stress and analyze the key role of oxidative stress in myogenesis. Then, we discuss the relationship between oxidative stress and muscle homeostasis and physiopathology. This work systematically summarizes the role of oxidative stress in myogenesis and muscle diseases and provides targets for subsequent antioxidant therapy and repair of inflammatory damage in noninflammatory muscle diseases.https://www.mdpi.com/2076-3921/11/4/755ROS/RNSoxidative stressmyogenesismuscle atrophyantioxidant therapy |
| spellingShingle | Di Lian Ming-Ming Chen Hanyu Wu Shoulong Deng Xiaoxiang Hu The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease Antioxidants ROS/RNS oxidative stress myogenesis muscle atrophy antioxidant therapy |
| title | The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease |
| title_full | The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease |
| title_fullStr | The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease |
| title_full_unstemmed | The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease |
| title_short | The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease |
| title_sort | role of oxidative stress in skeletal muscle myogenesis and muscle disease |
| topic | ROS/RNS oxidative stress myogenesis muscle atrophy antioxidant therapy |
| url | https://www.mdpi.com/2076-3921/11/4/755 |
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