CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in <i>Ldlr<sup>−/−</sup></i> Mice

CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in <i>Ldlr<sup>−/−</sup></i> Mice

Natural antibodies (NAbs) are important regulators of tissue homeostasis and inflammation and are thought to have diverse protective roles in a variety of pathological states. E06 is a T15 idiotype IgM NAb exclusively produced by B-1 cells, which recognizes the phosphocholine (PC) head group in oxid...

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Bibliographic Details
Main Authors: Tapan K. Biswas, Paul A. VanderLaan, Xuchu Que, Ayelet Gonen, Paulette Krishack, Christoph J. Binder, Joseph L. Witztum, Godfrey S. Getz, Catherine A. Reardon
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Antibodies
Subjects:
natural antibodies
CD1d
oxidized lipids
innate immunity
Online Access:https://www.mdpi.com/2073-4468/9/3/30

Internet

https://www.mdpi.com/2073-4468/9/3/30

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