Association of epicardial adipose tissue with different stages of coronary artery disease: A cross-sectional UK Biobank cardiovascular magnetic resonance imaging substudy
Objective: Increased epicardial adipose tissue (EAT) has been identified as a risk factor for the development of coronary artery disease (CAD). However, the exact role of EAT in the development of CAD is unclear. This study aims to compare EAT volumes between healthy controls and individuals with st...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906722000550 |
| _version_ | 1818213911395041280 |
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| author | Anne Ruth van Meijeren Daan Ties Marie-Sophie L.Y. de Koning Randy van Dijk Irene V. van Blokland Pablo Lizana Veloz Gijs van Woerden Rozemarijn Vliegenthart Gabija Pundziute Daan B. Westenbrink Pim van der Harst |
| author_facet | Anne Ruth van Meijeren Daan Ties Marie-Sophie L.Y. de Koning Randy van Dijk Irene V. van Blokland Pablo Lizana Veloz Gijs van Woerden Rozemarijn Vliegenthart Gabija Pundziute Daan B. Westenbrink Pim van der Harst |
| author_sort | Anne Ruth van Meijeren |
| collection | DOAJ |
| description | Objective: Increased epicardial adipose tissue (EAT) has been identified as a risk factor for the development of coronary artery disease (CAD). However, the exact role of EAT in the development of CAD is unclear. This study aims to compare EAT volumes between healthy controls and individuals with stable CAD and a history of myocardial infarction (MI). Furthermore, associations between clinical and biochemical parameters with EAT volumes are examined. Methods: This retrospective cross-sectional study included 171 participants from the United Kingdom Biobank (56 healthy controls; 60 stable CAD; 55 post MI), whom were balanced for age, sex and body mass index (BMI). EAT volumes were quantified on end-diastolic cardiac magnetic resonance (CMR) imaging short-axis slices along the left and right ventricle and indexed for body surface area (iEAT) and iEAT volumes were compared between groups. Results: iEAT volumes were comparable between control, CAD and MI cases (median [IQR]: 66.1[54.4–77.0] vs. 70.9[55.8–85.5] vs. 67.6[58.6–82.3] mL/m2, respectively (p > 0.005 for all). Increased HDL-cholesterol was associated with decreased iEAT volume (β = -14.8, CI = -24.6 to −4.97, p = 0.003) and suggestive associations (P-value < 0.05 and ≥ 0.005) were observed between iEAT and triglycerides (β = 3.26, CI = 0.42 to 6.09, p = 0.02), Apo-lipoprotein A (β = -16.3, CI = -30.3 to −2.24, p = 0.02) and LDL-cholesterol (β = 3.99, CI = -7.15 to −0.84, p = 0.01). Conclusions: No significant differences in iEAT volumes were observed between patients with CAD, MI and healthy controls. Our results indicate the importance of correcting for confounding by CVD risk factors, including circulating lipid levels, when studying the relationship between EAT volume and CAD. Further mechanistic studies on causal pathways and the role of EAT composition are warranted. |
| first_indexed | 2024-12-12T06:11:49Z |
| format | Article |
| id | doaj.art-a63f2f055ace4ccf89baa98784262d82 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-12T06:11:49Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-a63f2f055ace4ccf89baa98784262d822022-12-22T00:35:08ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672022-06-0140101006Association of epicardial adipose tissue with different stages of coronary artery disease: A cross-sectional UK Biobank cardiovascular magnetic resonance imaging substudyAnne Ruth van Meijeren0Daan Ties1Marie-Sophie L.Y. de Koning2Randy van Dijk3Irene V. van Blokland4Pablo Lizana Veloz5Gijs van Woerden6Rozemarijn Vliegenthart7Gabija Pundziute8Daan B. Westenbrink9Pim van der Harst10University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsFaculty of Medicine, University of Chile, Santiago, ChileUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsUniversity of Groningen, University Medical Center Groningen, Department of Radiology, Groningen, the NetherlandsUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the NetherlandsUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands; Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands; Corresponding author at: Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.Objective: Increased epicardial adipose tissue (EAT) has been identified as a risk factor for the development of coronary artery disease (CAD). However, the exact role of EAT in the development of CAD is unclear. This study aims to compare EAT volumes between healthy controls and individuals with stable CAD and a history of myocardial infarction (MI). Furthermore, associations between clinical and biochemical parameters with EAT volumes are examined. Methods: This retrospective cross-sectional study included 171 participants from the United Kingdom Biobank (56 healthy controls; 60 stable CAD; 55 post MI), whom were balanced for age, sex and body mass index (BMI). EAT volumes were quantified on end-diastolic cardiac magnetic resonance (CMR) imaging short-axis slices along the left and right ventricle and indexed for body surface area (iEAT) and iEAT volumes were compared between groups. Results: iEAT volumes were comparable between control, CAD and MI cases (median [IQR]: 66.1[54.4–77.0] vs. 70.9[55.8–85.5] vs. 67.6[58.6–82.3] mL/m2, respectively (p > 0.005 for all). Increased HDL-cholesterol was associated with decreased iEAT volume (β = -14.8, CI = -24.6 to −4.97, p = 0.003) and suggestive associations (P-value < 0.05 and ≥ 0.005) were observed between iEAT and triglycerides (β = 3.26, CI = 0.42 to 6.09, p = 0.02), Apo-lipoprotein A (β = -16.3, CI = -30.3 to −2.24, p = 0.02) and LDL-cholesterol (β = 3.99, CI = -7.15 to −0.84, p = 0.01). Conclusions: No significant differences in iEAT volumes were observed between patients with CAD, MI and healthy controls. Our results indicate the importance of correcting for confounding by CVD risk factors, including circulating lipid levels, when studying the relationship between EAT volume and CAD. Further mechanistic studies on causal pathways and the role of EAT composition are warranted.http://www.sciencedirect.com/science/article/pii/S2352906722000550Cardiovascular magnetic resonanceEpicardial adipose tissueLipidsCoronary artery diseaseMyocardial infarction |
| spellingShingle | Anne Ruth van Meijeren Daan Ties Marie-Sophie L.Y. de Koning Randy van Dijk Irene V. van Blokland Pablo Lizana Veloz Gijs van Woerden Rozemarijn Vliegenthart Gabija Pundziute Daan B. Westenbrink Pim van der Harst Association of epicardial adipose tissue with different stages of coronary artery disease: A cross-sectional UK Biobank cardiovascular magnetic resonance imaging substudy International Journal of Cardiology: Heart & Vasculature Cardiovascular magnetic resonance Epicardial adipose tissue Lipids Coronary artery disease Myocardial infarction |
| title | Association of epicardial adipose tissue with different stages of coronary artery disease: A cross-sectional UK Biobank cardiovascular magnetic resonance imaging substudy |
| title_full | Association of epicardial adipose tissue with different stages of coronary artery disease: A cross-sectional UK Biobank cardiovascular magnetic resonance imaging substudy |
| title_fullStr | Association of epicardial adipose tissue with different stages of coronary artery disease: A cross-sectional UK Biobank cardiovascular magnetic resonance imaging substudy |
| title_full_unstemmed | Association of epicardial adipose tissue with different stages of coronary artery disease: A cross-sectional UK Biobank cardiovascular magnetic resonance imaging substudy |
| title_short | Association of epicardial adipose tissue with different stages of coronary artery disease: A cross-sectional UK Biobank cardiovascular magnetic resonance imaging substudy |
| title_sort | association of epicardial adipose tissue with different stages of coronary artery disease a cross sectional uk biobank cardiovascular magnetic resonance imaging substudy |
| topic | Cardiovascular magnetic resonance Epicardial adipose tissue Lipids Coronary artery disease Myocardial infarction |
| url | http://www.sciencedirect.com/science/article/pii/S2352906722000550 |
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