Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease
Alzheimer’s disease (AD) was recently defined as a biological construct to reflect neuropathologic status, and both abnormal amyloid and tau are required for a diagnosis of AD. We aimed to determine the proton MR spectroscopic (<sup>1</sup>H-MRS) patterns of the posterior cingulate in bi...
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MDPI AG
2022-05-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/6/722 |
| _version_ | 1797489413765201920 |
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| author | Qianyun Chen Jill Abrigo Wanting Liu Elyia Yixun Han David Ka Wai Yeung Lin Shi Lisa Wing Chi Au Min Deng Sirong Chen Eric Yim Lung Leung Chi Lai Ho Vincent Chung Tong Mok Winnie Chiu Wing Chu |
| author_facet | Qianyun Chen Jill Abrigo Wanting Liu Elyia Yixun Han David Ka Wai Yeung Lin Shi Lisa Wing Chi Au Min Deng Sirong Chen Eric Yim Lung Leung Chi Lai Ho Vincent Chung Tong Mok Winnie Chiu Wing Chu |
| author_sort | Qianyun Chen |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) was recently defined as a biological construct to reflect neuropathologic status, and both abnormal amyloid and tau are required for a diagnosis of AD. We aimed to determine the proton MR spectroscopic (<sup>1</sup>H-MRS) patterns of the posterior cingulate in biologically defined AD. A total of 68 participants were included in this study, comprising 37 controls, 16 early AD, and 15 late AD, who were classified according to their amyloid and tau status and presence of hippocampal atrophy. Compared with controls, early AD showed lower N-acetylaspartate (NAA)/creatine (Cr) (<i>p</i> = 0.003), whereas late AD showed lower NAA/Cr and higher myoInositol (mI)/Cr (all with <i>p</i> < 0.05). Lower NAA/Cr correlated with a greater global amyloid load (<i>r</i> = −0.47, <i>p</i> < 0.001) and tau load (<i>r</i> = −0.51, <i>p</i> < 0.001) and allowed a discrimination of early AD from controls (<i>p</i> < 0.001). Subgroup analysis showed that NAA/Cr also allowed a differentiation of early AD from controls in the cognitively unimpaired subjects, with an area under the receiver operating characteristics curve, sensitivity, and specificity of 0.96, 100%, and 83.8%, respectively. Lower posterior cingulate NAA levels may help to inform underlying neuropathologic changes in the early stage of AD. |
| first_indexed | 2024-03-10T00:17:12Z |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T00:17:12Z |
| publishDate | 2022-05-01 |
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| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-a63f49cacbc64badadeb66100835f1712023-11-23T15:50:22ZengMDPI AGBrain Sciences2076-34252022-05-0112672210.3390/brainsci12060722Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s DiseaseQianyun Chen0Jill Abrigo1Wanting Liu2Elyia Yixun Han3David Ka Wai Yeung4Lin Shi5Lisa Wing Chi Au6Min Deng7Sirong Chen8Eric Yim Lung Leung9Chi Lai Ho10Vincent Chung Tong Mok11Winnie Chiu Wing Chu12Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, ChinaDepartment of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, ChinaDepartment of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, ChinaDepartment of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, ChinaDepartment of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, ChinaDepartment of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, ChinaDepartment of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, ChinaDepartment of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, ChinaDepartment of Nuclear Medicine & Positron Emission Tomography, Hong Kong Sanatorium & Hospital, Hong Kong SAR, ChinaDepartment of Nuclear Medicine & Positron Emission Tomography, Hong Kong Sanatorium & Hospital, Hong Kong SAR, ChinaDepartment of Nuclear Medicine & Positron Emission Tomography, Hong Kong Sanatorium & Hospital, Hong Kong SAR, ChinaDepartment of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, ChinaDepartment of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, ChinaAlzheimer’s disease (AD) was recently defined as a biological construct to reflect neuropathologic status, and both abnormal amyloid and tau are required for a diagnosis of AD. We aimed to determine the proton MR spectroscopic (<sup>1</sup>H-MRS) patterns of the posterior cingulate in biologically defined AD. A total of 68 participants were included in this study, comprising 37 controls, 16 early AD, and 15 late AD, who were classified according to their amyloid and tau status and presence of hippocampal atrophy. Compared with controls, early AD showed lower N-acetylaspartate (NAA)/creatine (Cr) (<i>p</i> = 0.003), whereas late AD showed lower NAA/Cr and higher myoInositol (mI)/Cr (all with <i>p</i> < 0.05). Lower NAA/Cr correlated with a greater global amyloid load (<i>r</i> = −0.47, <i>p</i> < 0.001) and tau load (<i>r</i> = −0.51, <i>p</i> < 0.001) and allowed a discrimination of early AD from controls (<i>p</i> < 0.001). Subgroup analysis showed that NAA/Cr also allowed a differentiation of early AD from controls in the cognitively unimpaired subjects, with an area under the receiver operating characteristics curve, sensitivity, and specificity of 0.96, 100%, and 83.8%, respectively. Lower posterior cingulate NAA levels may help to inform underlying neuropathologic changes in the early stage of AD.https://www.mdpi.com/2076-3425/12/6/722Alzheimer’s diseasemagnetic resonance spectroscopyN-acetylaspartate |
| spellingShingle | Qianyun Chen Jill Abrigo Wanting Liu Elyia Yixun Han David Ka Wai Yeung Lin Shi Lisa Wing Chi Au Min Deng Sirong Chen Eric Yim Lung Leung Chi Lai Ho Vincent Chung Tong Mok Winnie Chiu Wing Chu Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease Brain Sciences Alzheimer’s disease magnetic resonance spectroscopy N-acetylaspartate |
| title | Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease |
| title_full | Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease |
| title_fullStr | Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease |
| title_full_unstemmed | Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease |
| title_short | Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease |
| title_sort | lower posterior cingulate n acetylaspartate to creatine level in early detection of biologically defined alzheimer s disease |
| topic | Alzheimer’s disease magnetic resonance spectroscopy N-acetylaspartate |
| url | https://www.mdpi.com/2076-3425/12/6/722 |
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