Mental Illnesses in Inflammatory Bowel Diseases: <i>mens sana in corpore sano</i>
<i>Background and aims</i>: Inflammatory bowel diseases (IBD) are chronic disorders associated with a reduced quality of life, and patients often also suffer from psychiatric comorbidities. Overall, both mood and cognitive disorders are prevalent in chronic organic diseases, especially i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/4/682 |
| _version_ | 1797604473834569728 |
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| author | Bianca Bartocci Arianna Dal Buono Roberto Gabbiadini Anita Busacca Alessandro Quadarella Alessandro Repici Emanuela Mencaglia Linda Gasparini Alessandro Armuzzi |
| author_facet | Bianca Bartocci Arianna Dal Buono Roberto Gabbiadini Anita Busacca Alessandro Quadarella Alessandro Repici Emanuela Mencaglia Linda Gasparini Alessandro Armuzzi |
| author_sort | Bianca Bartocci |
| collection | DOAJ |
| description | <i>Background and aims</i>: Inflammatory bowel diseases (IBD) are chronic disorders associated with a reduced quality of life, and patients often also suffer from psychiatric comorbidities. Overall, both mood and cognitive disorders are prevalent in chronic organic diseases, especially in the case of a strong immune component, such as rheumatoid arthritis, multiple sclerosis, and cancer. Divergent data regarding the true incidence and prevalence of mental disorders in patients with IBD are available. We aimed to review the current evidence on the topic and the burden of mental illness in IBD patients, the role of the brain–gut axis in their co-existence, and its implication in an integrated clinical management. <i>Methods</i>: PubMed was searched to identify relevant studies investigating the gut–brain interactions and the incidence and prevalence of psychiatric disorders, especially of depression, anxiety, and cognitive dysfunction in the IBD population. <i>Results</i>: Among IBD patients, there is a high prevalence of psychiatric comorbidities, especially of anxiety and depression. Approximately 20–30% of IBD patients are affected by mood disorders and/or present with anxiety symptoms. Furthermore, it has been observed that the prevalence of mental illnesses increases in patients with active intestinal disease. Psychiatric comorbidities continue to be under-diagnosed in IBD patients and remain an unresolved issue in the management of these patients. <i>Conclusions</i>: Psychiatric illnesses co-occurring in IBD patients deserve acknowledgment from IBD specialists. These comorbidities highly impact the management of IBD patients and should be studied as an adjunctive therapeutic target. |
| first_indexed | 2024-03-11T04:46:24Z |
| format | Article |
| id | doaj.art-a640a054bfaa45a8951ded3d9b9ae3b3 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T04:46:24Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-a640a054bfaa45a8951ded3d9b9ae3b32023-11-17T20:20:28ZengMDPI AGMedicina1010-660X1648-91442023-03-0159468210.3390/medicina59040682Mental Illnesses in Inflammatory Bowel Diseases: <i>mens sana in corpore sano</i>Bianca Bartocci0Arianna Dal Buono1Roberto Gabbiadini2Anita Busacca3Alessandro Quadarella4Alessandro Repici5Emanuela Mencaglia6Linda Gasparini7Alessandro Armuzzi8IBD Center, Humanitas Research Hospital-IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, ItalyIBD Center, Humanitas Research Hospital-IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, ItalyIBD Center, Humanitas Research Hospital-IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, ItalyIBD Center, Humanitas Research Hospital-IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, ItalyIBD Center, Humanitas Research Hospital-IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, ItalyMedical Oncology and Haematology Unit, Humanitas Cancer Center, Humanitas Research Hospital IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, ItalyChild Neuropsychiatry Unit, Niguarda Hospital, 20162 Milan, ItalyIBD Center, Humanitas Research Hospital-IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, Italy<i>Background and aims</i>: Inflammatory bowel diseases (IBD) are chronic disorders associated with a reduced quality of life, and patients often also suffer from psychiatric comorbidities. Overall, both mood and cognitive disorders are prevalent in chronic organic diseases, especially in the case of a strong immune component, such as rheumatoid arthritis, multiple sclerosis, and cancer. Divergent data regarding the true incidence and prevalence of mental disorders in patients with IBD are available. We aimed to review the current evidence on the topic and the burden of mental illness in IBD patients, the role of the brain–gut axis in their co-existence, and its implication in an integrated clinical management. <i>Methods</i>: PubMed was searched to identify relevant studies investigating the gut–brain interactions and the incidence and prevalence of psychiatric disorders, especially of depression, anxiety, and cognitive dysfunction in the IBD population. <i>Results</i>: Among IBD patients, there is a high prevalence of psychiatric comorbidities, especially of anxiety and depression. Approximately 20–30% of IBD patients are affected by mood disorders and/or present with anxiety symptoms. Furthermore, it has been observed that the prevalence of mental illnesses increases in patients with active intestinal disease. Psychiatric comorbidities continue to be under-diagnosed in IBD patients and remain an unresolved issue in the management of these patients. <i>Conclusions</i>: Psychiatric illnesses co-occurring in IBD patients deserve acknowledgment from IBD specialists. These comorbidities highly impact the management of IBD patients and should be studied as an adjunctive therapeutic target.https://www.mdpi.com/1648-9144/59/4/682mental illnessesinflammatory bowel diseasedisabilityanxietyquality of life |
| spellingShingle | Bianca Bartocci Arianna Dal Buono Roberto Gabbiadini Anita Busacca Alessandro Quadarella Alessandro Repici Emanuela Mencaglia Linda Gasparini Alessandro Armuzzi Mental Illnesses in Inflammatory Bowel Diseases: <i>mens sana in corpore sano</i> Medicina mental illnesses inflammatory bowel disease disability anxiety quality of life |
| title | Mental Illnesses in Inflammatory Bowel Diseases: <i>mens sana in corpore sano</i> |
| title_full | Mental Illnesses in Inflammatory Bowel Diseases: <i>mens sana in corpore sano</i> |
| title_fullStr | Mental Illnesses in Inflammatory Bowel Diseases: <i>mens sana in corpore sano</i> |
| title_full_unstemmed | Mental Illnesses in Inflammatory Bowel Diseases: <i>mens sana in corpore sano</i> |
| title_short | Mental Illnesses in Inflammatory Bowel Diseases: <i>mens sana in corpore sano</i> |
| title_sort | mental illnesses in inflammatory bowel diseases i mens sana in corpore sano i |
| topic | mental illnesses inflammatory bowel disease disability anxiety quality of life |
| url | https://www.mdpi.com/1648-9144/59/4/682 |
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