The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus
Background: Diabetes mellitus (DM) is among the diseases with high morbidity and mortality The pathogenesis of DM involves pancreatic ß-cell damage or insulin sensitivity disorder that result in hyperglycemia. Tapak liman (Elephantopus scaber L) is known to have high flavonoid content. Flavonoids ar...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine
2020-08-01
|
| Series: | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| Subjects: | |
| Online Access: | https://journal.uii.ac.id/JKKI/article/view/13115 |
| _version_ | 1797785389367296000 |
|---|---|
| author | Tri Agusti Sholikah Sri Wulandari Indah Ariesta Muhammad Arif Rakhman Hakim Muhammad Hafizhan |
| author_facet | Tri Agusti Sholikah Sri Wulandari Indah Ariesta Muhammad Arif Rakhman Hakim Muhammad Hafizhan |
| author_sort | Tri Agusti Sholikah |
| collection | DOAJ |
| description | Background: Diabetes mellitus (DM) is among the diseases with high morbidity and mortality The pathogenesis of DM involves pancreatic ß-cell damage or insulin sensitivity disorder that result in hyperglycemia. Tapak liman (Elephantopus scaber L) is known to have high flavonoid content. Flavonoids are antioxidants that play a role in reducing pancreatic ß-cell damage or damage to other tissues, which potentially reduce blood glucose levels.
Objective: To determine the hypoglycemic effects of tapak liman using the DM rat models.
Methods: Twenty-eight Wistar albino rats (Rattus novergicus) were divided into four groups: the normal control group (KKn), not induced by streptozotocin-nicotinamide (STZ-NA) intraperitoneal; negative control group (KK-), induced by STZ-NA; treatment group 1 (KP1), induced by STZ-NA and 150 mg/kg body weight of tapak liman plant extract; and the treatment group 2 (KP2), induced by STZ-NA and 300 mg/kg body weight of tapak liman. Blood glucose levels were measured on the 7th day after STZ-NA induction and the 28th day after the administration of tapak liman plant extract. The results were analyzed for statistical significance.
Results: There was a significant decrease in blood glucose levels in KP1 and KP2 (p= 0.05). The decrease in blood glucose in KP1 had not reached normal levels compared to KP2.
Conclusion: Administration of tapak liman plant extract at a dose of 300 mg/kg body weight in DM rat models reduced blood glucose levels to normal. |
| first_indexed | 2024-03-13T00:54:24Z |
| format | Article |
| id | doaj.art-a641db96fae84316b717559942ab67bf |
| institution | Directory Open Access Journal |
| issn | 2085-4145 2527-2950 |
| language | English |
| last_indexed | 2024-03-13T00:54:24Z |
| publishDate | 2020-08-01 |
| publisher | Faculty of Medicine |
| record_format | Article |
| series | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| spelling | doaj.art-a641db96fae84316b717559942ab67bf2023-07-07T07:41:36ZengFaculty of MedicineJKKI (Jurnal Kedokteran dan Kesehatan Indonesia)2085-41452527-29502020-08-0117217910.20885/JKKI.Vol11.Iss2.art1010772The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitusTri Agusti Sholikah0Sri Wulandari1Indah Ariesta2Muhammad Arif Rakhman Hakim3Muhammad Hafizhan4Department of Histology, Faculty of Medicine, Universitas Sebelas Maret, SurakartaDepartment of Physiology, Faculty of Medicine, Universitas Sebelas Maret, SurakartaUndergraduate student, Faculty of Medicine, Universitas Sebelas Maret, SurakartaUndergraduate student, Faculty of Medicine, Universitas Sebelas Maret, SurakartaUndergraduate student, Faculty of Medicine, Universitas Sebelas Maret, SurakartaBackground: Diabetes mellitus (DM) is among the diseases with high morbidity and mortality The pathogenesis of DM involves pancreatic ß-cell damage or insulin sensitivity disorder that result in hyperglycemia. Tapak liman (Elephantopus scaber L) is known to have high flavonoid content. Flavonoids are antioxidants that play a role in reducing pancreatic ß-cell damage or damage to other tissues, which potentially reduce blood glucose levels. Objective: To determine the hypoglycemic effects of tapak liman using the DM rat models. Methods: Twenty-eight Wistar albino rats (Rattus novergicus) were divided into four groups: the normal control group (KKn), not induced by streptozotocin-nicotinamide (STZ-NA) intraperitoneal; negative control group (KK-), induced by STZ-NA; treatment group 1 (KP1), induced by STZ-NA and 150 mg/kg body weight of tapak liman plant extract; and the treatment group 2 (KP2), induced by STZ-NA and 300 mg/kg body weight of tapak liman. Blood glucose levels were measured on the 7th day after STZ-NA induction and the 28th day after the administration of tapak liman plant extract. The results were analyzed for statistical significance. Results: There was a significant decrease in blood glucose levels in KP1 and KP2 (p= 0.05). The decrease in blood glucose in KP1 had not reached normal levels compared to KP2. Conclusion: Administration of tapak liman plant extract at a dose of 300 mg/kg body weight in DM rat models reduced blood glucose levels to normal.https://journal.uii.ac.id/JKKI/article/view/13115elephantopus scaber lflavanoiddm rat model |
| spellingShingle | Tri Agusti Sholikah Sri Wulandari Indah Ariesta Muhammad Arif Rakhman Hakim Muhammad Hafizhan The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) elephantopus scaber l flavanoid dm rat model |
| title | The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus |
| title_full | The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus |
| title_fullStr | The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus |
| title_full_unstemmed | The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus |
| title_short | The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus |
| title_sort | hypoglicemic effects of tapak liman elephantopus scaber l plant extract on albino rat rattus novergicus models of diabetes mellitus |
| topic | elephantopus scaber l flavanoid dm rat model |
| url | https://journal.uii.ac.id/JKKI/article/view/13115 |
| work_keys_str_mv | AT triagustisholikah thehypoglicemiceffectsoftapaklimanelephantopusscaberlplantextractonalbinoratrattusnovergicusmodelsofdiabetesmellitus AT sriwulandari thehypoglicemiceffectsoftapaklimanelephantopusscaberlplantextractonalbinoratrattusnovergicusmodelsofdiabetesmellitus AT indahariesta thehypoglicemiceffectsoftapaklimanelephantopusscaberlplantextractonalbinoratrattusnovergicusmodelsofdiabetesmellitus AT muhammadarifrakhmanhakim thehypoglicemiceffectsoftapaklimanelephantopusscaberlplantextractonalbinoratrattusnovergicusmodelsofdiabetesmellitus AT muhammadhafizhan thehypoglicemiceffectsoftapaklimanelephantopusscaberlplantextractonalbinoratrattusnovergicusmodelsofdiabetesmellitus AT triagustisholikah hypoglicemiceffectsoftapaklimanelephantopusscaberlplantextractonalbinoratrattusnovergicusmodelsofdiabetesmellitus AT sriwulandari hypoglicemiceffectsoftapaklimanelephantopusscaberlplantextractonalbinoratrattusnovergicusmodelsofdiabetesmellitus AT indahariesta hypoglicemiceffectsoftapaklimanelephantopusscaberlplantextractonalbinoratrattusnovergicusmodelsofdiabetesmellitus AT muhammadarifrakhmanhakim hypoglicemiceffectsoftapaklimanelephantopusscaberlplantextractonalbinoratrattusnovergicusmodelsofdiabetesmellitus AT muhammadhafizhan hypoglicemiceffectsoftapaklimanelephantopusscaberlplantextractonalbinoratrattusnovergicusmodelsofdiabetesmellitus |