Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1.
There are at least two phases of beta-cell death during the development of autoimmune diabetes: an initiation event that results in the release of beta-cell-specific antigens, and a second, antigen-driven event in which beta-cell death is mediated by the actions of T lymphocytes. In this report, the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-02-01
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| Series: | PLoS Medicine |
| Online Access: | http://europepmc.org/articles/PMC1316065?pdf=render |