Goblet cell carcinoid of the rectum: a case report
Abstract Background Goblet cell carcinoid (GCC) is a neuroendocrine tumor usually found in the appendix. GCCs exhibit characteristic findings with mixed endocrine-exocrine features such as staining positive for neuroendocrine markers and producing mucin. The primary GCC of the rectum is exceedingly...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2020-07-01
|
| Series: | Surgical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40792-020-00937-3 |
| _version_ | 1819073024663486464 |
|---|---|
| author | Yoshiyuki Inoue Hisanaga Horie Yuko Homma Ai Sadatomo Makiko Tahara Koji Koinuma Hironori Yamaguchi Toshiki Mimura Atsushi Kihara Alan Kawarai Lefor Naohiro Sata |
| author_facet | Yoshiyuki Inoue Hisanaga Horie Yuko Homma Ai Sadatomo Makiko Tahara Koji Koinuma Hironori Yamaguchi Toshiki Mimura Atsushi Kihara Alan Kawarai Lefor Naohiro Sata |
| author_sort | Yoshiyuki Inoue |
| collection | DOAJ |
| description | Abstract Background Goblet cell carcinoid (GCC) is a neuroendocrine tumor usually found in the appendix. GCCs exhibit characteristic findings with mixed endocrine-exocrine features such as staining positive for neuroendocrine markers and producing mucin. The primary GCC of the rectum is exceedingly rare. Case presentation A 77-year-old Japanese male presented with hematochezia. Anal tenderness and a hard mass in the anal canal were found on the digital rectal examination, and colonoscopy was performed. Colonoscopy showed an irregularly shaped mass in the anal canal. Biopsy showed mixed features including adenocarcinoma in situ, well-differentiated adenocarcinoma, and mucinous carcinoma with invasive proliferation. No metastatic lesions were found on the computed tomography scan. Pelvic magnetic resonance imaging scan showed extramural growth of a tumor on the ventral side of the rectum without invasion to the prostate. Laparoscopic abdominoperineal resection was performed. The final diagnosis was well-differentiated adenocarcinoma in the mucosa and goblet cell carcinoid from the submucosa to the adventitia of the rectum. The patient was discharged from the hospital on postoperative day 16. Six months after resection, a computed tomography scan revealed multiple metastatic lesions in the liver. Several chemotherapy regimens were given, and the patient has stable disease 27 months after surgery. Conclusion We present a patient with rectal GCC with metachronous liver metastases. Since GCC grows intramurally and is biologically aggressive compared to typical carcinoid lesions, the disease is usually diagnosed at an advanced stage. The development of optimal adjuvant chemotherapy is needed for those patients. |
| first_indexed | 2024-12-21T17:47:03Z |
| format | Article |
| id | doaj.art-a642a080befe4fcdb9e381b0d28a63d4 |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-21T17:47:03Z |
| publishDate | 2020-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-a642a080befe4fcdb9e381b0d28a63d42022-12-21T18:55:28ZengSpringerOpenSurgical Case Reports2198-77932020-07-01611810.1186/s40792-020-00937-3Goblet cell carcinoid of the rectum: a case reportYoshiyuki Inoue0Hisanaga Horie1Yuko Homma2Ai Sadatomo3Makiko Tahara4Koji Koinuma5Hironori Yamaguchi6Toshiki Mimura7Atsushi Kihara8Alan Kawarai Lefor9Naohiro Sata10Department of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Pathology, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityAbstract Background Goblet cell carcinoid (GCC) is a neuroendocrine tumor usually found in the appendix. GCCs exhibit characteristic findings with mixed endocrine-exocrine features such as staining positive for neuroendocrine markers and producing mucin. The primary GCC of the rectum is exceedingly rare. Case presentation A 77-year-old Japanese male presented with hematochezia. Anal tenderness and a hard mass in the anal canal were found on the digital rectal examination, and colonoscopy was performed. Colonoscopy showed an irregularly shaped mass in the anal canal. Biopsy showed mixed features including adenocarcinoma in situ, well-differentiated adenocarcinoma, and mucinous carcinoma with invasive proliferation. No metastatic lesions were found on the computed tomography scan. Pelvic magnetic resonance imaging scan showed extramural growth of a tumor on the ventral side of the rectum without invasion to the prostate. Laparoscopic abdominoperineal resection was performed. The final diagnosis was well-differentiated adenocarcinoma in the mucosa and goblet cell carcinoid from the submucosa to the adventitia of the rectum. The patient was discharged from the hospital on postoperative day 16. Six months after resection, a computed tomography scan revealed multiple metastatic lesions in the liver. Several chemotherapy regimens were given, and the patient has stable disease 27 months after surgery. Conclusion We present a patient with rectal GCC with metachronous liver metastases. Since GCC grows intramurally and is biologically aggressive compared to typical carcinoid lesions, the disease is usually diagnosed at an advanced stage. The development of optimal adjuvant chemotherapy is needed for those patients.http://link.springer.com/article/10.1186/s40792-020-00937-3Goblet cell carcinoidRectumLiver metastases |
| spellingShingle | Yoshiyuki Inoue Hisanaga Horie Yuko Homma Ai Sadatomo Makiko Tahara Koji Koinuma Hironori Yamaguchi Toshiki Mimura Atsushi Kihara Alan Kawarai Lefor Naohiro Sata Goblet cell carcinoid of the rectum: a case report Surgical Case Reports Goblet cell carcinoid Rectum Liver metastases |
| title | Goblet cell carcinoid of the rectum: a case report |
| title_full | Goblet cell carcinoid of the rectum: a case report |
| title_fullStr | Goblet cell carcinoid of the rectum: a case report |
| title_full_unstemmed | Goblet cell carcinoid of the rectum: a case report |
| title_short | Goblet cell carcinoid of the rectum: a case report |
| title_sort | goblet cell carcinoid of the rectum a case report |
| topic | Goblet cell carcinoid Rectum Liver metastases |
| url | http://link.springer.com/article/10.1186/s40792-020-00937-3 |
| work_keys_str_mv | AT yoshiyukiinoue gobletcellcarcinoidoftherectumacasereport AT hisanagahorie gobletcellcarcinoidoftherectumacasereport AT yukohomma gobletcellcarcinoidoftherectumacasereport AT aisadatomo gobletcellcarcinoidoftherectumacasereport AT makikotahara gobletcellcarcinoidoftherectumacasereport AT kojikoinuma gobletcellcarcinoidoftherectumacasereport AT hironoriyamaguchi gobletcellcarcinoidoftherectumacasereport AT toshikimimura gobletcellcarcinoidoftherectumacasereport AT atsushikihara gobletcellcarcinoidoftherectumacasereport AT alankawarailefor gobletcellcarcinoidoftherectumacasereport AT naohirosata gobletcellcarcinoidoftherectumacasereport |