The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome
Viral non-structural proteins, such as NSs of the newly emerging severe fever with thrombocytopenia syndrome virus, are well established virulence factors, mediating viral pathogenesis and disease progression through various mechanisms. NSs has been described as a potent interferon antagonist and NF...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/5/876 |
| _version_ | 1797534684756836352 |
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| author | Jumana Khalil Hiroki Kato Takashi Fujita |
| author_facet | Jumana Khalil Hiroki Kato Takashi Fujita |
| author_sort | Jumana Khalil |
| collection | DOAJ |
| description | Viral non-structural proteins, such as NSs of the newly emerging severe fever with thrombocytopenia syndrome virus, are well established virulence factors, mediating viral pathogenesis and disease progression through various mechanisms. NSs has been described as a potent interferon antagonist and NF-κB agonist, two divergent signaling pathways in many immune responses upon a viral encounter. In this review, we highlight the many mechanisms used by NSs on the host that promote viral replication and hyper-inflammation. Understanding these host-pathogen interactions is crucial for antiviral therapy development. |
| first_indexed | 2024-03-10T11:32:57Z |
| format | Article |
| id | doaj.art-a644088734d840ea936aae20422d0a28 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T11:32:57Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a644088734d840ea936aae20422d0a282023-11-21T19:05:23ZengMDPI AGViruses1999-49152021-05-0113587610.3390/v13050876The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia SyndromeJumana Khalil0Hiroki Kato1Takashi Fujita2Laboratory of Virus Immunology, Institute for Frontier Life and Medical Science, Kyoto University, Kyoto 606-8507, JapanLaboratory of Virus Immunology, Institute for Frontier Life and Medical Science, Kyoto University, Kyoto 606-8507, JapanLaboratory of Virus Immunology, Institute for Frontier Life and Medical Science, Kyoto University, Kyoto 606-8507, JapanViral non-structural proteins, such as NSs of the newly emerging severe fever with thrombocytopenia syndrome virus, are well established virulence factors, mediating viral pathogenesis and disease progression through various mechanisms. NSs has been described as a potent interferon antagonist and NF-κB agonist, two divergent signaling pathways in many immune responses upon a viral encounter. In this review, we highlight the many mechanisms used by NSs on the host that promote viral replication and hyper-inflammation. Understanding these host-pathogen interactions is crucial for antiviral therapy development.https://www.mdpi.com/1999-4915/13/5/876SFTSV NSsNF-κBcytokine stormTBK1viral pathogenesisinterferons |
| spellingShingle | Jumana Khalil Hiroki Kato Takashi Fujita The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Viruses SFTSV NSs NF-κB cytokine storm TBK1 viral pathogenesis interferons |
| title | The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome |
| title_full | The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome |
| title_fullStr | The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome |
| title_full_unstemmed | The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome |
| title_short | The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome |
| title_sort | role of non structural protein nss in the pathogenesis of severe fever with thrombocytopenia syndrome |
| topic | SFTSV NSs NF-κB cytokine storm TBK1 viral pathogenesis interferons |
| url | https://www.mdpi.com/1999-4915/13/5/876 |
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