An Emerging Role of Defective Copper Metabolism in Heart Disease
Copper is an essential trace metal element that significantly affects human physiology and pathology by regulating various important biological processes, including mitochondrial oxidative phosphorylation, iron mobilization, connective tissue crosslinking, antioxidant defense, melanin synthesis, blo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/3/700 |
| _version_ | 1797485504014319616 |
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| author | Yun Liu Ji Miao |
| author_facet | Yun Liu Ji Miao |
| author_sort | Yun Liu |
| collection | DOAJ |
| description | Copper is an essential trace metal element that significantly affects human physiology and pathology by regulating various important biological processes, including mitochondrial oxidative phosphorylation, iron mobilization, connective tissue crosslinking, antioxidant defense, melanin synthesis, blood clotting, and neuron peptide maturation. Increasing lines of evidence obtained from studies of cell culture, animals, and human genetics have demonstrated that dysregulation of copper metabolism causes heart disease, which is the leading cause of mortality in the US. Defects of copper homeostasis caused by perturbed regulation of copper chaperones or copper transporters or by copper deficiency resulted in various types of heart disease, including cardiac hypertrophy, heart failure, ischemic heart disease, and diabetes mellitus cardiomyopathy. This review aims to provide a timely summary of the effects of defective copper homeostasis on heart disease and discuss potential underlying molecular mechanisms. |
| first_indexed | 2024-03-09T23:20:44Z |
| format | Article |
| id | doaj.art-a6446054c2a44294bc1aa733a945c714 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T23:20:44Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a6446054c2a44294bc1aa733a945c7142023-11-23T17:28:08ZengMDPI AGNutrients2072-66432022-02-0114370010.3390/nu14030700An Emerging Role of Defective Copper Metabolism in Heart DiseaseYun Liu0Ji Miao1Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, ChinaDivision of Endocrinology, Boston Children’s Hospital, Boston, MA 02115, USACopper is an essential trace metal element that significantly affects human physiology and pathology by regulating various important biological processes, including mitochondrial oxidative phosphorylation, iron mobilization, connective tissue crosslinking, antioxidant defense, melanin synthesis, blood clotting, and neuron peptide maturation. Increasing lines of evidence obtained from studies of cell culture, animals, and human genetics have demonstrated that dysregulation of copper metabolism causes heart disease, which is the leading cause of mortality in the US. Defects of copper homeostasis caused by perturbed regulation of copper chaperones or copper transporters or by copper deficiency resulted in various types of heart disease, including cardiac hypertrophy, heart failure, ischemic heart disease, and diabetes mellitus cardiomyopathy. This review aims to provide a timely summary of the effects of defective copper homeostasis on heart disease and discuss potential underlying molecular mechanisms.https://www.mdpi.com/2072-6643/14/3/700copper chaperonecopper transportercopper deficiencyheart disease |
| spellingShingle | Yun Liu Ji Miao An Emerging Role of Defective Copper Metabolism in Heart Disease Nutrients copper chaperone copper transporter copper deficiency heart disease |
| title | An Emerging Role of Defective Copper Metabolism in Heart Disease |
| title_full | An Emerging Role of Defective Copper Metabolism in Heart Disease |
| title_fullStr | An Emerging Role of Defective Copper Metabolism in Heart Disease |
| title_full_unstemmed | An Emerging Role of Defective Copper Metabolism in Heart Disease |
| title_short | An Emerging Role of Defective Copper Metabolism in Heart Disease |
| title_sort | emerging role of defective copper metabolism in heart disease |
| topic | copper chaperone copper transporter copper deficiency heart disease |
| url | https://www.mdpi.com/2072-6643/14/3/700 |
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