The Xanthate Route to Amino Acids
The degenerative xanthate addition transfer to alkenes allows the synthesis of a broad range of protected, and in some cases enantiopure, α, β, and γ-amino acids, including proline and pipecolic derivatives, as well as fluorinated congeners and β-lactams. The radical addition furnishes naturally lat...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2020-02-01
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| Series: | CHIMIA |
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| Online Access: | https://www.ingentaconnect.com/contentone/scs/chimia/2020/00000074/00000001/art00003 |
| _version_ | 1818286145064140800 |
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| author | Samir Z. Zard |
| author_facet | Samir Z. Zard |
| author_sort | Samir Z. Zard |
| collection | DOAJ |
| description | The degenerative xanthate addition transfer to alkenes allows the synthesis of a broad range of protected, and in some cases enantiopure, α, β, and γ-amino acids, including proline and pipecolic derivatives, as well as fluorinated congeners and β-lactams. The radical addition furnishes naturally latent mercapto-α-amino acids that are ideally equipped for native chemical ligation. Most of the amino acid structures accessible rapidly by this chemistry would otherwise require tedious multi-step syntheses. |
| first_indexed | 2024-12-13T01:19:56Z |
| format | Article |
| id | doaj.art-a645ede86e564ba2b048b4cbcea556dc |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-13T01:19:56Z |
| publishDate | 2020-02-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-a645ede86e564ba2b048b4cbcea556dc2022-12-22T00:04:16ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242020-02-01741/291710.2533/chimia.2020.9The Xanthate Route to Amino AcidsSamir Z. Zard0Laboratoire de Synthèse Organique, UMR 7652, Ecole Polytechnique, 91128 Palaiseau, FranceThe degenerative xanthate addition transfer to alkenes allows the synthesis of a broad range of protected, and in some cases enantiopure, α, β, and γ-amino acids, including proline and pipecolic derivatives, as well as fluorinated congeners and β-lactams. The radical addition furnishes naturally latent mercapto-α-amino acids that are ideally equipped for native chemical ligation. Most of the amino acid structures accessible rapidly by this chemistry would otherwise require tedious multi-step syntheses.https://www.ingentaconnect.com/contentone/scs/chimia/2020/00000074/00000001/art00003amino acidsnative chemical ligationradical additionxanthates |
| spellingShingle | Samir Z. Zard The Xanthate Route to Amino Acids CHIMIA amino acids native chemical ligation radical addition xanthates |
| title | The Xanthate Route to Amino Acids |
| title_full | The Xanthate Route to Amino Acids |
| title_fullStr | The Xanthate Route to Amino Acids |
| title_full_unstemmed | The Xanthate Route to Amino Acids |
| title_short | The Xanthate Route to Amino Acids |
| title_sort | xanthate route to amino acids |
| topic | amino acids native chemical ligation radical addition xanthates |
| url | https://www.ingentaconnect.com/contentone/scs/chimia/2020/00000074/00000001/art00003 |
| work_keys_str_mv | AT samirzzard thexanthateroutetoaminoacids AT samirzzard xanthateroutetoaminoacids |