BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography
Ovarian cancer typically presents at advanced stage with intra-abdominal metastases. Rarely, ovarian cancer presents with distant metastases with little to no intra-abdominal disease burden. The patient was a BRCA-2 germline mutation carrier diagnosed with a Stage IVB high-grade carcinoma of the fal...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578920301569 |
| _version_ | 1818369479660273664 |
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| author | Janelle N. Sobecki Kathryn A. Dryer Aparna M. Mahajan Ryan J. Spencer |
| author_facet | Janelle N. Sobecki Kathryn A. Dryer Aparna M. Mahajan Ryan J. Spencer |
| author_sort | Janelle N. Sobecki |
| collection | DOAJ |
| description | Ovarian cancer typically presents at advanced stage with intra-abdominal metastases. Rarely, ovarian cancer presents with distant metastases with little to no intra-abdominal disease burden. The patient was a BRCA-2 germline mutation carrier diagnosed with a Stage IVB high-grade carcinoma of the fallopian tube following discovery of a right axillary breast mass on screening mammography. Pre-operative imaging was without evidence of metastatic disease in the abdomen or pelvis. She underwent surgical staging followed by adjuvant chemotherapy and maintenance poly-ADP ribose polymerase (PARP) inhibition. She is without evidence of disease 24 months following her surgical staging procedure. An isolated oligo metastasis in the axilla is a rare presentation of ovarian carcinoma. Extra-abdominal metastases can present a diagnostic challenge in ovarian cancer necessitating thorough pathologic and radiologic work-up, particularly in the absence of intra-abdominal disease. |
| first_indexed | 2024-12-13T23:24:30Z |
| format | Article |
| id | doaj.art-a6489996b2344147ad2c56324ba323c1 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-12-13T23:24:30Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-a6489996b2344147ad2c56324ba323c12022-12-21T23:27:35ZengElsevierGynecologic Oncology Reports2352-57892021-02-0135100690BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammographyJanelle N. Sobecki0Kathryn A. Dryer1Aparna M. Mahajan2Ryan J. Spencer3Division of Gynecologic Oncology, University of Wisconsin-Madison School of Medicine and Public Health, United States; Corresponding author at: 600 Highland Ave. H4/676, Madison, WI 53792, United States.Department of Obstetrics & Gynecology, University of Wisconsin-Madison School of Medicine and Public Health, United StatesDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, United StatesDivision of Gynecologic Oncology, University of Wisconsin-Madison School of Medicine and Public Health, United StatesOvarian cancer typically presents at advanced stage with intra-abdominal metastases. Rarely, ovarian cancer presents with distant metastases with little to no intra-abdominal disease burden. The patient was a BRCA-2 germline mutation carrier diagnosed with a Stage IVB high-grade carcinoma of the fallopian tube following discovery of a right axillary breast mass on screening mammography. Pre-operative imaging was without evidence of metastatic disease in the abdomen or pelvis. She underwent surgical staging followed by adjuvant chemotherapy and maintenance poly-ADP ribose polymerase (PARP) inhibition. She is without evidence of disease 24 months following her surgical staging procedure. An isolated oligo metastasis in the axilla is a rare presentation of ovarian carcinoma. Extra-abdominal metastases can present a diagnostic challenge in ovarian cancer necessitating thorough pathologic and radiologic work-up, particularly in the absence of intra-abdominal disease.http://www.sciencedirect.com/science/article/pii/S2352578920301569Ovarian cancer distant metastasisBRCA-2Breast massPARP inhibitor |
| spellingShingle | Janelle N. Sobecki Kathryn A. Dryer Aparna M. Mahajan Ryan J. Spencer BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography Gynecologic Oncology Reports Ovarian cancer distant metastasis BRCA-2 Breast mass PARP inhibitor |
| title | BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography |
| title_full | BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography |
| title_fullStr | BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography |
| title_full_unstemmed | BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography |
| title_short | BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography |
| title_sort | brca 2 high grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography |
| topic | Ovarian cancer distant metastasis BRCA-2 Breast mass PARP inhibitor |
| url | http://www.sciencedirect.com/science/article/pii/S2352578920301569 |
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