Constriction Channel Based Single-Cell Mechanical Property Characterization
This mini-review presents recent progresses in the development of microfluidic constriction channels enabling high-throughput mechanical property characterization of single cells. We first summarized the applications of the constriction channel design in quantifying mechanical properties of various...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-11-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-666X/6/11/1457 |
| _version_ | 1818920795846475776 |
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| author | Chengcheng Xue Junbo Wang Yang Zhao Deyong Chen Wentao Yue Jian Chen |
| author_facet | Chengcheng Xue Junbo Wang Yang Zhao Deyong Chen Wentao Yue Jian Chen |
| author_sort | Chengcheng Xue |
| collection | DOAJ |
| description | This mini-review presents recent progresses in the development of microfluidic constriction channels enabling high-throughput mechanical property characterization of single cells. We first summarized the applications of the constriction channel design in quantifying mechanical properties of various types of cells including red blood cells, white blood cells, and tumor cells. Then we highlighted the efforts in modeling the cellular entry process into the constriction channel, enabling the translation of raw mechanical data (e.g., cellular entry time into the constriction channel) into intrinsic cellular mechanical properties such as cortical tension or Young’s modulus. In the end, current limitations and future research opportunities of the microfluidic constriction channels were discussed. |
| first_indexed | 2024-12-20T01:27:26Z |
| format | Article |
| id | doaj.art-a648e73c18fd44f4ba5623695d35b126 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-20T01:27:26Z |
| publishDate | 2015-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-a648e73c18fd44f4ba5623695d35b1262022-12-21T19:58:11ZengMDPI AGMicromachines2072-666X2015-11-016111794180410.3390/mi6111457mi6111457Constriction Channel Based Single-Cell Mechanical Property CharacterizationChengcheng Xue0Junbo Wang1Yang Zhao2Deyong Chen3Wentao Yue4Jian Chen5State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, ChinaState Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, ChinaState Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, ChinaState Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, ChinaDepartment of Cellular and Molecular Biology, Beijing Chest Hospital, Capital Medical University, Beijing101149, ChinaState Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, ChinaThis mini-review presents recent progresses in the development of microfluidic constriction channels enabling high-throughput mechanical property characterization of single cells. We first summarized the applications of the constriction channel design in quantifying mechanical properties of various types of cells including red blood cells, white blood cells, and tumor cells. Then we highlighted the efforts in modeling the cellular entry process into the constriction channel, enabling the translation of raw mechanical data (e.g., cellular entry time into the constriction channel) into intrinsic cellular mechanical properties such as cortical tension or Young’s modulus. In the end, current limitations and future research opportunities of the microfluidic constriction channels were discussed.http://www.mdpi.com/2072-666X/6/11/1457single-cell analysismicrofluidicsconstriction channelmechanical property characterizationhigh throughput |
| spellingShingle | Chengcheng Xue Junbo Wang Yang Zhao Deyong Chen Wentao Yue Jian Chen Constriction Channel Based Single-Cell Mechanical Property Characterization Micromachines single-cell analysis microfluidics constriction channel mechanical property characterization high throughput |
| title | Constriction Channel Based Single-Cell Mechanical Property Characterization |
| title_full | Constriction Channel Based Single-Cell Mechanical Property Characterization |
| title_fullStr | Constriction Channel Based Single-Cell Mechanical Property Characterization |
| title_full_unstemmed | Constriction Channel Based Single-Cell Mechanical Property Characterization |
| title_short | Constriction Channel Based Single-Cell Mechanical Property Characterization |
| title_sort | constriction channel based single cell mechanical property characterization |
| topic | single-cell analysis microfluidics constriction channel mechanical property characterization high throughput |
| url | http://www.mdpi.com/2072-666X/6/11/1457 |
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