An ecological study of obesity-related cancer incidence trends in Australia from 1983 to 2017
Summary: Background: Overweight and obesity is a growing public health issue as it contributes to the future burden of obesity-related diseases, including cancer, especially in high-income countries. In Australia, 4.3% of all cancers diagnosed in 2013 were attributable to overweight and obesity. Ou...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | The Lancet Regional Health. Western Pacific |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666606522001900 |
| _version_ | 1811275916631867392 |
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| author | Eleonora Feletto Ankur Kohar David Mizrahi Paul Grogan Julia Steinberg Clare Hughes Wendy L. Watson Karen Canfell Xue Qin Yu |
| author_facet | Eleonora Feletto Ankur Kohar David Mizrahi Paul Grogan Julia Steinberg Clare Hughes Wendy L. Watson Karen Canfell Xue Qin Yu |
| author_sort | Eleonora Feletto |
| collection | DOAJ |
| description | Summary: Background: Overweight and obesity is a growing public health issue as it contributes to the future burden of obesity-related diseases, including cancer, especially in high-income countries. In Australia, 4.3% of all cancers diagnosed in 2013 were attributable to overweight and obesity. Our aim was to examine Australian age-specific incidence trends over the last 35 years for obesity-related cancers based on expert review (colorectal, liver, gallbladder, pancreas, breast in postmenopausal women, uterine, ovary, kidney, thyroid, and multiple myeloma) individually and pooled. Methods: Australian incidence data for 10 obesity-related cancers among people aged 25–84 years, diagnosed from 1983 to 2017, were obtained from the Australian Cancer Database. We used age–period–cohort modelling and joinpoint analysis to assess trends, estimating incidence rate ratios (IRR) by birth-cohort for each individual cancer and pooled, and the annual percentage change. The analyses were also conducted for non-obesity-related cancers over the same period. Findings: The total number of cancers where some proportion is obesity-related, diagnosed from 1983-2017, was 1,005,933. This grouping was 34.7% of cancers diagnosed. The IRR of obesity-related cancers increased from 0.77 (95% CI 0.73, 0.81) for the 1903 birth-cohort to 2.95 (95% CI 2.58, 3.38) for the recent 1988 cohort relative to the 1943 cohort. The IRRs of non-obesity related cancers were stable with non-significant decreases in younger cohorts. These trends were broadly similar across sex and age groups. Interpretation: The incidence of obesity-related cancers in Australia has increased by birth-cohort across all age-groups, which should be monitored. Obesity, a public health epidemic, needs to be addressed through increased awareness, policy support and evidence-based interventions. Funding: This research received no specific funding. |
| first_indexed | 2024-04-12T23:46:02Z |
| format | Article |
| id | doaj.art-a649e90ef12e4b919a4b6600317f95ae |
| institution | Directory Open Access Journal |
| issn | 2666-6065 |
| language | English |
| last_indexed | 2024-04-12T23:46:02Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Western Pacific |
| spelling | doaj.art-a649e90ef12e4b919a4b6600317f95ae2022-12-22T03:11:51ZengElsevierThe Lancet Regional Health. Western Pacific2666-60652022-12-0129100575An ecological study of obesity-related cancer incidence trends in Australia from 1983 to 2017Eleonora Feletto0Ankur Kohar1David Mizrahi2Paul Grogan3Julia Steinberg4Clare Hughes5Wendy L. Watson6Karen Canfell7Xue Qin Yu8The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Australia; Corresponding author at: The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, 153 Dowling Street, Woolloomooloo, NSW 2011, Australia.The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, AustraliaThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, AustraliaThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, AustraliaThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, AustraliaCancer Prevention and Advocacy Division, Cancer Council NSW, AustraliaCancer Prevention and Advocacy Division, Cancer Council NSW, AustraliaThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, AustraliaThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, AustraliaSummary: Background: Overweight and obesity is a growing public health issue as it contributes to the future burden of obesity-related diseases, including cancer, especially in high-income countries. In Australia, 4.3% of all cancers diagnosed in 2013 were attributable to overweight and obesity. Our aim was to examine Australian age-specific incidence trends over the last 35 years for obesity-related cancers based on expert review (colorectal, liver, gallbladder, pancreas, breast in postmenopausal women, uterine, ovary, kidney, thyroid, and multiple myeloma) individually and pooled. Methods: Australian incidence data for 10 obesity-related cancers among people aged 25–84 years, diagnosed from 1983 to 2017, were obtained from the Australian Cancer Database. We used age–period–cohort modelling and joinpoint analysis to assess trends, estimating incidence rate ratios (IRR) by birth-cohort for each individual cancer and pooled, and the annual percentage change. The analyses were also conducted for non-obesity-related cancers over the same period. Findings: The total number of cancers where some proportion is obesity-related, diagnosed from 1983-2017, was 1,005,933. This grouping was 34.7% of cancers diagnosed. The IRR of obesity-related cancers increased from 0.77 (95% CI 0.73, 0.81) for the 1903 birth-cohort to 2.95 (95% CI 2.58, 3.38) for the recent 1988 cohort relative to the 1943 cohort. The IRRs of non-obesity related cancers were stable with non-significant decreases in younger cohorts. These trends were broadly similar across sex and age groups. Interpretation: The incidence of obesity-related cancers in Australia has increased by birth-cohort across all age-groups, which should be monitored. Obesity, a public health epidemic, needs to be addressed through increased awareness, policy support and evidence-based interventions. Funding: This research received no specific funding.http://www.sciencedirect.com/science/article/pii/S2666606522001900CancerObesityOverweightAge–period–cohortIncidence |
| spellingShingle | Eleonora Feletto Ankur Kohar David Mizrahi Paul Grogan Julia Steinberg Clare Hughes Wendy L. Watson Karen Canfell Xue Qin Yu An ecological study of obesity-related cancer incidence trends in Australia from 1983 to 2017 The Lancet Regional Health. Western Pacific Cancer Obesity Overweight Age–period–cohort Incidence |
| title | An ecological study of obesity-related cancer incidence trends in Australia from 1983 to 2017 |
| title_full | An ecological study of obesity-related cancer incidence trends in Australia from 1983 to 2017 |
| title_fullStr | An ecological study of obesity-related cancer incidence trends in Australia from 1983 to 2017 |
| title_full_unstemmed | An ecological study of obesity-related cancer incidence trends in Australia from 1983 to 2017 |
| title_short | An ecological study of obesity-related cancer incidence trends in Australia from 1983 to 2017 |
| title_sort | ecological study of obesity related cancer incidence trends in australia from 1983 to 2017 |
| topic | Cancer Obesity Overweight Age–period–cohort Incidence |
| url | http://www.sciencedirect.com/science/article/pii/S2666606522001900 |
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