Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea
Biomarkers are not available for monitoring the onset and progression of coronary artery disease (CAD) in patients with obstructive sleep apnea (OSA), a major risk factor for arteriosclerotic cardiovascular diseases. This study aimed to test for correlation between circulating anti-Sorting Nexins 16...
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MDPI AG
2020-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/2/71 |
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| author | Yusuke Katsumata Jiro Terada Takuma Matsumura Ken Koshikawa Seiichiro Sakao Go Tomiyoshi Natsuko Shinmen Rika Nakamura Hideyuki Kuroda Kengo Nagashima Yoshio Kobayashi Eiichi Kobayashi Yasuo Iwadate Xiao-Meng Zhang Takaki Hiwasa Koichiro Tatsumi |
| author_facet | Yusuke Katsumata Jiro Terada Takuma Matsumura Ken Koshikawa Seiichiro Sakao Go Tomiyoshi Natsuko Shinmen Rika Nakamura Hideyuki Kuroda Kengo Nagashima Yoshio Kobayashi Eiichi Kobayashi Yasuo Iwadate Xiao-Meng Zhang Takaki Hiwasa Koichiro Tatsumi |
| author_sort | Yusuke Katsumata |
| collection | DOAJ |
| description | Biomarkers are not available for monitoring the onset and progression of coronary artery disease (CAD) in patients with obstructive sleep apnea (OSA), a major risk factor for arteriosclerotic cardiovascular diseases. This study aimed to test for correlation between circulating anti-Sorting Nexins 16 antibody (SNX16-Ab) levels, CAD history and clinical parameters of patients with OSA. Sixty-four healthy donors, 82 adults with OSA, and 96 with acute coronary syndrome (ACS) were studied. Serum samples were collected at diagnostic polysomnography in the OSA group or at the disease onset in the ACS group. Serum SNX16-Ab levels were measured by amplified luminescence proximity homogeneous assay (AlphaLISA), and correlation between SNX16-Ab levels and clinical parameters was analyzed. SNX16-Ab levels and apnea-hypopnea index (AHI) were weakly correlated. Additionally, logistic regression analyses of OSA group identified that elevated SNX16-Ab level associated with the history of CAD. Circulating SNX16-Ab could increase during CAD pathogenesis in patients with OSA. Further prospective studies are required to prove the predictive potential of SNX16-Ab level in CAD onset of patients with OSA. |
| first_indexed | 2024-04-13T07:18:11Z |
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| language | English |
| last_indexed | 2024-04-13T07:18:11Z |
| publishDate | 2020-01-01 |
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| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-a64bebeb23ab4a53bc75f74056eaf5202022-12-22T02:56:42ZengMDPI AGDiagnostics2075-44182020-01-011027110.3390/diagnostics10020071diagnostics10020071Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep ApneaYusuke Katsumata0Jiro Terada1Takuma Matsumura2Ken Koshikawa3Seiichiro Sakao4Go Tomiyoshi5Natsuko Shinmen6Rika Nakamura7Hideyuki Kuroda8Kengo Nagashima9Yoshio Kobayashi10Eiichi Kobayashi11Yasuo Iwadate12Xiao-Meng Zhang13Takaki Hiwasa14Koichiro Tatsumi15Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanFujikura Kasei Co.,Ltd., Minato-ku, Tokyo 105-0011, JapanFujikura Kasei Co.,Ltd., Minato-ku, Tokyo 105-0011, JapanFujikura Kasei Co.,Ltd., Minato-ku, Tokyo 105-0011, JapanFujikura Kasei Co.,Ltd., Minato-ku, Tokyo 105-0011, JapanResearch Center for Medical and Health Data Science, The Institute of Statistical Mathematics, Tokyo 190-8562, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanBiomarkers are not available for monitoring the onset and progression of coronary artery disease (CAD) in patients with obstructive sleep apnea (OSA), a major risk factor for arteriosclerotic cardiovascular diseases. This study aimed to test for correlation between circulating anti-Sorting Nexins 16 antibody (SNX16-Ab) levels, CAD history and clinical parameters of patients with OSA. Sixty-four healthy donors, 82 adults with OSA, and 96 with acute coronary syndrome (ACS) were studied. Serum samples were collected at diagnostic polysomnography in the OSA group or at the disease onset in the ACS group. Serum SNX16-Ab levels were measured by amplified luminescence proximity homogeneous assay (AlphaLISA), and correlation between SNX16-Ab levels and clinical parameters was analyzed. SNX16-Ab levels and apnea-hypopnea index (AHI) were weakly correlated. Additionally, logistic regression analyses of OSA group identified that elevated SNX16-Ab level associated with the history of CAD. Circulating SNX16-Ab could increase during CAD pathogenesis in patients with OSA. Further prospective studies are required to prove the predictive potential of SNX16-Ab level in CAD onset of patients with OSA.https://www.mdpi.com/2075-4418/10/2/71atherosclerosisautoantibodybiomarkercoronary arteryobstructive sleep apnea |
| spellingShingle | Yusuke Katsumata Jiro Terada Takuma Matsumura Ken Koshikawa Seiichiro Sakao Go Tomiyoshi Natsuko Shinmen Rika Nakamura Hideyuki Kuroda Kengo Nagashima Yoshio Kobayashi Eiichi Kobayashi Yasuo Iwadate Xiao-Meng Zhang Takaki Hiwasa Koichiro Tatsumi Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea Diagnostics atherosclerosis autoantibody biomarker coronary artery obstructive sleep apnea |
| title | Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea |
| title_full | Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea |
| title_fullStr | Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea |
| title_full_unstemmed | Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea |
| title_short | Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea |
| title_sort | circulating anti sorting nexins 16 antibodies as an emerging biomarker of coronary artery disease in patients with obstructive sleep apnea |
| topic | atherosclerosis autoantibody biomarker coronary artery obstructive sleep apnea |
| url | https://www.mdpi.com/2075-4418/10/2/71 |
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