Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis.
<h4>Objective</h4>To investigate the effectiveness of exercise and/or educational intervention on physical activity and pain in patients with hip/knee osteoarthritis (OA) using systematic review and meta-analysis.<h4>Methods</h4>We searched randomized controlled trials that i...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0275591 |
| _version_ | 1797978096664576000 |
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| author | Ryo Sasaki Yuichiro Honda Satoshi Oga Takuya Fukushima Natsumi Tanaka Yasuhiro Kajiwara Koichi Nakagawa Ayumi Takahashi Yukinori Sakamoto Hinako Morita Yutaro Kondo Seima Okita Yasutaka Kondo Kyo Goto Hideki Kataoka Junya Sakamoto Minoru Okita |
| author_facet | Ryo Sasaki Yuichiro Honda Satoshi Oga Takuya Fukushima Natsumi Tanaka Yasuhiro Kajiwara Koichi Nakagawa Ayumi Takahashi Yukinori Sakamoto Hinako Morita Yutaro Kondo Seima Okita Yasutaka Kondo Kyo Goto Hideki Kataoka Junya Sakamoto Minoru Okita |
| author_sort | Ryo Sasaki |
| collection | DOAJ |
| description | <h4>Objective</h4>To investigate the effectiveness of exercise and/or educational intervention on physical activity and pain in patients with hip/knee osteoarthritis (OA) using systematic review and meta-analysis.<h4>Methods</h4>We searched randomized controlled trials that investigated physical activity and pain and compared exercise and/or educational intervention with usual care in patients with hip/knee OA in MEDLINE (PubMed), ProQuest, Scopus, and the Physiotherapy Evidence Database (PEDro), including all those published by April 30, 2022 and written in English. Studies that newly applied analgesics after onset of the intervention were excluded. The revised Cochrane risk-of-bias tool for randomized trials was used to assess the methodological qualities. The random-effects model was used for meta-analysis with standard mean differences using RevMan version 5.4. The body of evidence for each study was synthesized using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.<h4>Results</h4>Twenty studies including 2,350 patients were included (7 exercise studies, 8 educational intervention studies and 5 combination studies). The meta-analysis demonstrated that there is very low evidence that combination therapy of exercise and educational intervention improve the physical activity level at the endpoint (4 articles; SMD 0.33, 95% CI 0.04 to 0.51, P = 0.03). Low evidence was observed for combination therapy reducing pain (4 articles; SMD -0.15, 95% CI -0.29 to -0.02, P = 0.03).<h4>Discussion</h4>The current evidence indicated that combination therapy of exercise and educational intervention leads to improved physical activity and pain reduction in hip/knee OA patients, but the risk of bias in each study, especially in allocation concealment, downgraded the evidence level. These findings support the use of a combination therapy of exercise and educational intervention to promote physical activity levels in patients with hip/knee OA.<h4>Trail registration</h4>There was no financial support for this research. The protocol was registered at the International Prospective Register of Systematic Reviews (registration code: CRD42020205804). |
| first_indexed | 2024-04-11T05:17:35Z |
| format | Article |
| id | doaj.art-a6527c9341704cd8bea8bd6c56546427 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T05:17:35Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a6527c9341704cd8bea8bd6c565464272022-12-24T05:33:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011711e027559110.1371/journal.pone.0275591Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis.Ryo SasakiYuichiro HondaSatoshi OgaTakuya FukushimaNatsumi TanakaYasuhiro KajiwaraKoichi NakagawaAyumi TakahashiYukinori SakamotoHinako MoritaYutaro KondoSeima OkitaYasutaka KondoKyo GotoHideki KataokaJunya SakamotoMinoru Okita<h4>Objective</h4>To investigate the effectiveness of exercise and/or educational intervention on physical activity and pain in patients with hip/knee osteoarthritis (OA) using systematic review and meta-analysis.<h4>Methods</h4>We searched randomized controlled trials that investigated physical activity and pain and compared exercise and/or educational intervention with usual care in patients with hip/knee OA in MEDLINE (PubMed), ProQuest, Scopus, and the Physiotherapy Evidence Database (PEDro), including all those published by April 30, 2022 and written in English. Studies that newly applied analgesics after onset of the intervention were excluded. The revised Cochrane risk-of-bias tool for randomized trials was used to assess the methodological qualities. The random-effects model was used for meta-analysis with standard mean differences using RevMan version 5.4. The body of evidence for each study was synthesized using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.<h4>Results</h4>Twenty studies including 2,350 patients were included (7 exercise studies, 8 educational intervention studies and 5 combination studies). The meta-analysis demonstrated that there is very low evidence that combination therapy of exercise and educational intervention improve the physical activity level at the endpoint (4 articles; SMD 0.33, 95% CI 0.04 to 0.51, P = 0.03). Low evidence was observed for combination therapy reducing pain (4 articles; SMD -0.15, 95% CI -0.29 to -0.02, P = 0.03).<h4>Discussion</h4>The current evidence indicated that combination therapy of exercise and educational intervention leads to improved physical activity and pain reduction in hip/knee OA patients, but the risk of bias in each study, especially in allocation concealment, downgraded the evidence level. These findings support the use of a combination therapy of exercise and educational intervention to promote physical activity levels in patients with hip/knee OA.<h4>Trail registration</h4>There was no financial support for this research. The protocol was registered at the International Prospective Register of Systematic Reviews (registration code: CRD42020205804).https://doi.org/10.1371/journal.pone.0275591 |
| spellingShingle | Ryo Sasaki Yuichiro Honda Satoshi Oga Takuya Fukushima Natsumi Tanaka Yasuhiro Kajiwara Koichi Nakagawa Ayumi Takahashi Yukinori Sakamoto Hinako Morita Yutaro Kondo Seima Okita Yasutaka Kondo Kyo Goto Hideki Kataoka Junya Sakamoto Minoru Okita Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis. PLoS ONE |
| title | Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis. |
| title_full | Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis. |
| title_fullStr | Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis. |
| title_full_unstemmed | Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis. |
| title_short | Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis. |
| title_sort | effect of exercise and or educational interventions on physical activity and pain in patients with hip knee osteoarthritis a systematic review with meta analysis |
| url | https://doi.org/10.1371/journal.pone.0275591 |
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