Knockdown of insulin-like growth factor 1 exerts a protective effect on hypoxic injury of aged BM-MSCs: role of autophagy

Knockdown of insulin-like growth factor 1 exerts a protective effect on hypoxic injury of aged BM-MSCs: role of autophagy

Abstract Background Treatment with bone marrow mesenchymal stem cells (BM-MSCs) has been demonstrated to be an excellent cellular-based therapeutic strategy for treating myocardial infarction (MI). However, most of the patients suffering with MI are elderly. Hypoxic conditions can cause apoptosis of...

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Bibliographic Details
Main Authors: Ming Yang, Tong Wen, Haixu Chen, Jingyu Deng, Chao Yang, Zheng Zhang
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Stem Cell Research & Therapy
Subjects:
AMPK/mTOR
IGF-1 knockdown
Bone marrow-mesenchymal stem cells
Apoptosis
Autophagy
Hypoxic condition
Online Access:http://link.springer.com/article/10.1186/s13287-018-1028-5

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