Wound monitoring of pH and oxygen in patients after radiation therapy
Abstract Objectives Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this study was to evaluate a 2D luminescence imaging system for pH and oxygen i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-019-1413-y |
| _version_ | 1818151768523014144 |
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| author | Steffen Auerswald Stephan Schreml Robert Meier Alexandra Blancke Soares Maximilian Niyazi Sebastian Marschner Claus Belka Martin Canis Frank Haubner |
| author_facet | Steffen Auerswald Stephan Schreml Robert Meier Alexandra Blancke Soares Maximilian Niyazi Sebastian Marschner Claus Belka Martin Canis Frank Haubner |
| author_sort | Steffen Auerswald |
| collection | DOAJ |
| description | Abstract Objectives Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this study was to evaluate a 2D luminescence imaging system for pH and oxygen in non-healing wounds after radiotherapy. Methods Luminescence 2D imaging was performed with the VisiSens (Presens, Regensburg, Germany) 2D imaging systems A1 and A2 for oxygen and pH, respectively. Biocompatible planar luminescent sensor foils were applied to non-irradiated and irradiated skin as well as to radiogenic wounds of five patients and the pH and the oxygen saturation was determined. Results pH measurements showed significant differences between non-irradiated skin (6.46 ± 0.18) and irradiated skin (6.96 ± 0.26). Radiogenic wounds exhibited the highest pH values (7.53 ± 0.26). Oxygen measurements revealed a mean oxygen saturation of non-irradiated skin of 6.19 ± 0.83 mmHg. The highest value of oxygen saturation (28.4 ± 2.4 mmHg) was found on irradiated skin while irradiated wounds had a poor oxygen saturation (9.4 ± 2.2 mmHg) (mean ± s.e.m.). Conclusion We found that routine measurement of pH and pO2 in patients could be easily integrated into the clinical routine. The results of the measurements show unfavorable pH and oxygen saturation conditions for wound healing in irradiated wounds. Interestingly, irradiated wounds exhibit a more pronounced hypoxia than irradiated skin which is reflected by an altered pH and pO2 compared to unirradiated skin, which has the potential to serve as a prognostic marker in the future. In addition to the objectification of the treatment success of postradiogenic wound healing disorders, the extent of skin toxicity could already be predicted during radiotherapy with this method. |
| first_indexed | 2024-12-11T13:44:04Z |
| format | Article |
| id | doaj.art-a652ff23444f4d77b105c6fce08eb9a6 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-11T13:44:04Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-a652ff23444f4d77b105c6fce08eb9a62022-12-22T01:04:38ZengBMCRadiation Oncology1748-717X2019-11-011411910.1186/s13014-019-1413-yWound monitoring of pH and oxygen in patients after radiation therapySteffen Auerswald0Stephan Schreml1Robert Meier2Alexandra Blancke Soares3Maximilian Niyazi4Sebastian Marschner5Claus Belka6Martin Canis7Frank Haubner8Department of Otorhinolaryngology, University Medical Center RegensburgDepartment of Dermatology, University Medical Center RegensburgPresensDepartment of Otorhinolaryngology, University Medical Center Munich, Klinikum GroßhadernDepartment of Radiation Oncology, University Medical Center MunichGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)Department of Radiation Oncology, University Medical Center MunichDepartment of Otorhinolaryngology, University Medical Center Munich, Klinikum GroßhadernDepartment of Otorhinolaryngology, University Medical Center Munich, Klinikum GroßhadernAbstract Objectives Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this study was to evaluate a 2D luminescence imaging system for pH and oxygen in non-healing wounds after radiotherapy. Methods Luminescence 2D imaging was performed with the VisiSens (Presens, Regensburg, Germany) 2D imaging systems A1 and A2 for oxygen and pH, respectively. Biocompatible planar luminescent sensor foils were applied to non-irradiated and irradiated skin as well as to radiogenic wounds of five patients and the pH and the oxygen saturation was determined. Results pH measurements showed significant differences between non-irradiated skin (6.46 ± 0.18) and irradiated skin (6.96 ± 0.26). Radiogenic wounds exhibited the highest pH values (7.53 ± 0.26). Oxygen measurements revealed a mean oxygen saturation of non-irradiated skin of 6.19 ± 0.83 mmHg. The highest value of oxygen saturation (28.4 ± 2.4 mmHg) was found on irradiated skin while irradiated wounds had a poor oxygen saturation (9.4 ± 2.2 mmHg) (mean ± s.e.m.). Conclusion We found that routine measurement of pH and pO2 in patients could be easily integrated into the clinical routine. The results of the measurements show unfavorable pH and oxygen saturation conditions for wound healing in irradiated wounds. Interestingly, irradiated wounds exhibit a more pronounced hypoxia than irradiated skin which is reflected by an altered pH and pO2 compared to unirradiated skin, which has the potential to serve as a prognostic marker in the future. In addition to the objectification of the treatment success of postradiogenic wound healing disorders, the extent of skin toxicity could already be predicted during radiotherapy with this method.http://link.springer.com/article/10.1186/s13014-019-1413-yWound healingRadiotherapyLuminescencepHOxygen |
| spellingShingle | Steffen Auerswald Stephan Schreml Robert Meier Alexandra Blancke Soares Maximilian Niyazi Sebastian Marschner Claus Belka Martin Canis Frank Haubner Wound monitoring of pH and oxygen in patients after radiation therapy Radiation Oncology Wound healing Radiotherapy Luminescence pH Oxygen |
| title | Wound monitoring of pH and oxygen in patients after radiation therapy |
| title_full | Wound monitoring of pH and oxygen in patients after radiation therapy |
| title_fullStr | Wound monitoring of pH and oxygen in patients after radiation therapy |
| title_full_unstemmed | Wound monitoring of pH and oxygen in patients after radiation therapy |
| title_short | Wound monitoring of pH and oxygen in patients after radiation therapy |
| title_sort | wound monitoring of ph and oxygen in patients after radiation therapy |
| topic | Wound healing Radiotherapy Luminescence pH Oxygen |
| url | http://link.springer.com/article/10.1186/s13014-019-1413-y |
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