Plasma levels and diagnostic utility of macrophage-colony stimulating factor, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 as tumor markers in cervical cancer patients
Macrophage-colony stimulating factor, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 may play an important role in malignant processes. The aim of this study was to investigate the diagnostic power of those parameters (serological biomarkers) in comparison to cancer antigen...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOS Press
2018-07-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428318790363 |
| _version_ | 1819091196575744000 |
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| author | Monika Zajkowska Monika Zbucka-Krętowska Iwona Sidorkiewicz Emilia Lubowicka Ewa Gacuta Maciej Szmitkowski Lech Chrostek Sławomir Ławicki |
| author_facet | Monika Zajkowska Monika Zbucka-Krętowska Iwona Sidorkiewicz Emilia Lubowicka Ewa Gacuta Maciej Szmitkowski Lech Chrostek Sławomir Ławicki |
| author_sort | Monika Zajkowska |
| collection | DOAJ |
| description | Macrophage-colony stimulating factor, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 may play an important role in malignant processes. The aim of this study was to investigate the diagnostic power of those parameters (serological biomarkers) in comparison to cancer antigen 125 and squamous cell carcinoma antigen in cervical cancer patients and in relation to the control groups. The study included 100 cervical cancer patients, 50 patients with cervical ectropion and 50 healthy women. Plasma levels of tested parameters were determined by enzyme-linked immunosorbent assay, cancer antigen 125, and squamous cell carcinoma antigen by chemiluminescent microparticle immunoassay. Plasma levels of all parameters in the total cancer group showed statistical significance (in all cases p < 0.05). In stage I of cancer only medial supraclavicular fossa and tissue inhibitor of metalloproteinase-1, in stage II all the tested parameters and cancer antigen 125, and in stage III + IV macrophage-colony stimulating factor, matrix metalloproteinase-9, and cancer antigen 125 showed statistical significance when compared to the healthy volunteers group. Macrophage-colony stimulating factor showed the highest value of sensitivity from all tested parameters (I: 56.25%, II: 72.73%, III + IV: 77.14% and 69% in total cervical cancer group). The highest specificity was obtained by matrix metalloproteinase-9 (94%). Positive predictive values were highest also for matrix metalloproteinase-9 (I: 82.35%, II: 84.21%, III + IV: 88% and 94.55% in total cervical cancer group), negative predictive values for macrophage-colony stimulating factor (I: 75.44%, II: 82.69%, III + IV: 87.5% and 58.11% in total cervical cancer group) and tumor markers. In the total cervical cancer group, all tested parameters showed statistically significant areas under receiver operating characteristic curve, but maximum range was obtained for the combination macrophage-colony stimulating factor + squamous cell carcinoma antigen (0.8723). The combined analysis of tested parameters and tumor markers resulted in an increase in sensitivity and areas under receiver operating characteristic curve values, which provides hope for developing new panel of biomarkers that may be used in the diagnosis of cervical cancer in the future. |
| first_indexed | 2024-12-21T22:35:53Z |
| format | Article |
| id | doaj.art-a6533e51d7f4455380e4b5e5e9cdbfaf |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-21T22:35:53Z |
| publishDate | 2018-07-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-a6533e51d7f4455380e4b5e5e9cdbfaf2022-12-21T18:47:57ZengIOS PressTumor Biology1423-03802018-07-014010.1177/1010428318790363Plasma levels and diagnostic utility of macrophage-colony stimulating factor, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 as tumor markers in cervical cancer patientsMonika Zajkowska0Monika Zbucka-Krętowska1Iwona Sidorkiewicz2Emilia Lubowicka3Ewa Gacuta4Maciej Szmitkowski5Lech Chrostek6Sławomir Ławicki7Department of Biochemical Diagnostics, Medical University of Białystok, Białystok, PolandDepartment of Reproduction and Gynecological Endocrinology, Medical University of Białystok, Białystok, PolandDepartment of Reproduction and Gynecological Endocrinology, Medical University of Białystok, Białystok, PolandDepartment of Esthetic Medicine, Medical University of Białystok, Białystok, PolandDepartment of Perinatology, Medical University of Białystok, Białystok, PolandDepartment of Biochemical Diagnostics, Medical University of Białystok, Białystok, PolandDepartment of Biochemical Diagnostics, Medical University of Białystok, Białystok, PolandDepartment of Biochemical Diagnostics, Medical University of Białystok, Białystok, PolandMacrophage-colony stimulating factor, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 may play an important role in malignant processes. The aim of this study was to investigate the diagnostic power of those parameters (serological biomarkers) in comparison to cancer antigen 125 and squamous cell carcinoma antigen in cervical cancer patients and in relation to the control groups. The study included 100 cervical cancer patients, 50 patients with cervical ectropion and 50 healthy women. Plasma levels of tested parameters were determined by enzyme-linked immunosorbent assay, cancer antigen 125, and squamous cell carcinoma antigen by chemiluminescent microparticle immunoassay. Plasma levels of all parameters in the total cancer group showed statistical significance (in all cases p < 0.05). In stage I of cancer only medial supraclavicular fossa and tissue inhibitor of metalloproteinase-1, in stage II all the tested parameters and cancer antigen 125, and in stage III + IV macrophage-colony stimulating factor, matrix metalloproteinase-9, and cancer antigen 125 showed statistical significance when compared to the healthy volunteers group. Macrophage-colony stimulating factor showed the highest value of sensitivity from all tested parameters (I: 56.25%, II: 72.73%, III + IV: 77.14% and 69% in total cervical cancer group). The highest specificity was obtained by matrix metalloproteinase-9 (94%). Positive predictive values were highest also for matrix metalloproteinase-9 (I: 82.35%, II: 84.21%, III + IV: 88% and 94.55% in total cervical cancer group), negative predictive values for macrophage-colony stimulating factor (I: 75.44%, II: 82.69%, III + IV: 87.5% and 58.11% in total cervical cancer group) and tumor markers. In the total cervical cancer group, all tested parameters showed statistically significant areas under receiver operating characteristic curve, but maximum range was obtained for the combination macrophage-colony stimulating factor + squamous cell carcinoma antigen (0.8723). The combined analysis of tested parameters and tumor markers resulted in an increase in sensitivity and areas under receiver operating characteristic curve values, which provides hope for developing new panel of biomarkers that may be used in the diagnosis of cervical cancer in the future.https://doi.org/10.1177/1010428318790363 |
| spellingShingle | Monika Zajkowska Monika Zbucka-Krętowska Iwona Sidorkiewicz Emilia Lubowicka Ewa Gacuta Maciej Szmitkowski Lech Chrostek Sławomir Ławicki Plasma levels and diagnostic utility of macrophage-colony stimulating factor, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 as tumor markers in cervical cancer patients Tumor Biology |
| title | Plasma levels and diagnostic utility of macrophage-colony stimulating factor, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 as tumor markers in cervical cancer patients |
| title_full | Plasma levels and diagnostic utility of macrophage-colony stimulating factor, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 as tumor markers in cervical cancer patients |
| title_fullStr | Plasma levels and diagnostic utility of macrophage-colony stimulating factor, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 as tumor markers in cervical cancer patients |
| title_full_unstemmed | Plasma levels and diagnostic utility of macrophage-colony stimulating factor, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 as tumor markers in cervical cancer patients |
| title_short | Plasma levels and diagnostic utility of macrophage-colony stimulating factor, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 as tumor markers in cervical cancer patients |
| title_sort | plasma levels and diagnostic utility of macrophage colony stimulating factor matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 as tumor markers in cervical cancer patients |
| url | https://doi.org/10.1177/1010428318790363 |
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