Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

Paneth cells are key epithelial cells that provide an antimicrobial barrier and maintain integrity of the small-intestinal stem cell niche. Paneth cell abnormalities are unfortunately detrimental to gut health and are often associated with digestive pathologies such as Crohn's disease or infect...

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Bibliographic Details
Main Authors: Emily J. Jones, Zoe J. Matthews, Lejla Gul, Padhmanand Sudhakar, Agatha Treveil, Devina Divekar, Jasmine Buck, Tomasz Wrzesinski, Matthew Jefferson, Stuart D. Armstrong, Lindsay J. Hall, Alastair J. M. Watson, Simon R. Carding, Wilfried Haerty, Federica Di Palma, Ulrike Mayer, Penny P. Powell, Isabelle Hautefort, Tom Wileman, Tamas Korcsmaros
Format: Article
Language:English
Published: The Company of Biologists 2019-03-01
Series:Disease Models & Mechanisms
Subjects:
Paneth cells
Atg16l1
Intestinal organoids
Quantitative proteomics
Selective autophagy
Online Access:http://dmm.biologists.org/content/12/3/dmm037069

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