The Anti-Cancer Effects of Frondoside A
Frondoside A is a triterpenoid glycoside from the Atlantic Sea Cucumber, Cucumaria frondosa. Frondoside A has a broad spectrum of anti-cancer effects, including induction of cellular apoptosis, inhibition of cancer cell growth, migration, invasion, formation of metastases, and angiogenesis. In cell...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/2/64 |
| _version_ | 1828391348047183872 |
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| author | Thomas E. Adrian Peter Collin |
| author_facet | Thomas E. Adrian Peter Collin |
| author_sort | Thomas E. Adrian |
| collection | DOAJ |
| description | Frondoside A is a triterpenoid glycoside from the Atlantic Sea Cucumber, Cucumaria frondosa. Frondoside A has a broad spectrum of anti-cancer effects, including induction of cellular apoptosis, inhibition of cancer cell growth, migration, invasion, formation of metastases, and angiogenesis. In cell lines and animal models studied to date, the anti-cancer effects of the compound are seen in all solid cancers, lymphomas, and leukemias studied to date. These effects appear to be due to potent inhibition of p21-activated kinase 1 (PAK1), which is up-regulated in many cancers. In mouse models, frondoside A has synergistic effects with conventional chemotherapeutic agents, such as gemcitabine, paclitaxel, and cisplatin. Frondoside A administration is well-tolerated. No side effects have been reported and the compound has no significant effects on body weight, blood cells, or on hepatic and renal function tests after long-term administration. Frondoside A may be valuable in the treatment of malignancies, either as a single agent or in combination with other therapeutic modalities. |
| first_indexed | 2024-12-10T07:00:25Z |
| format | Article |
| id | doaj.art-a655bc3c164c4eb4a5329a1b1027a3e2 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-12-10T07:00:25Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a655bc3c164c4eb4a5329a1b1027a3e22022-12-22T01:58:21ZengMDPI AGMarine Drugs1660-33972018-02-011626410.3390/md16020064md16020064The Anti-Cancer Effects of Frondoside AThomas E. Adrian0Peter Collin1Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab EmiratesCoastside Bio Resources, Deer Isle, ME 04627, USAFrondoside A is a triterpenoid glycoside from the Atlantic Sea Cucumber, Cucumaria frondosa. Frondoside A has a broad spectrum of anti-cancer effects, including induction of cellular apoptosis, inhibition of cancer cell growth, migration, invasion, formation of metastases, and angiogenesis. In cell lines and animal models studied to date, the anti-cancer effects of the compound are seen in all solid cancers, lymphomas, and leukemias studied to date. These effects appear to be due to potent inhibition of p21-activated kinase 1 (PAK1), which is up-regulated in many cancers. In mouse models, frondoside A has synergistic effects with conventional chemotherapeutic agents, such as gemcitabine, paclitaxel, and cisplatin. Frondoside A administration is well-tolerated. No side effects have been reported and the compound has no significant effects on body weight, blood cells, or on hepatic and renal function tests after long-term administration. Frondoside A may be valuable in the treatment of malignancies, either as a single agent or in combination with other therapeutic modalities.http://www.mdpi.com/1660-3397/16/2/64cancerfrondoside Atumor growthmetastasesapoptosisinvasionangiogenesis |
| spellingShingle | Thomas E. Adrian Peter Collin The Anti-Cancer Effects of Frondoside A Marine Drugs cancer frondoside A tumor growth metastases apoptosis invasion angiogenesis |
| title | The Anti-Cancer Effects of Frondoside A |
| title_full | The Anti-Cancer Effects of Frondoside A |
| title_fullStr | The Anti-Cancer Effects of Frondoside A |
| title_full_unstemmed | The Anti-Cancer Effects of Frondoside A |
| title_short | The Anti-Cancer Effects of Frondoside A |
| title_sort | anti cancer effects of frondoside a |
| topic | cancer frondoside A tumor growth metastases apoptosis invasion angiogenesis |
| url | http://www.mdpi.com/1660-3397/16/2/64 |
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