Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics
Summary: Degraded DNA is used to answer questions in the fields of ancient DNA (aDNA) and forensic genetics. While aDNA studies typically center around human evolution and past history, and forensic genetics is often more concerned with identifying a specific individual, scientists in both fields fa...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223021430 |
| _version_ | 1797653636211277824 |
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| author | Ainash Childebayeva Elena I. Zavala |
| author_facet | Ainash Childebayeva Elena I. Zavala |
| author_sort | Ainash Childebayeva |
| collection | DOAJ |
| description | Summary: Degraded DNA is used to answer questions in the fields of ancient DNA (aDNA) and forensic genetics. While aDNA studies typically center around human evolution and past history, and forensic genetics is often more concerned with identifying a specific individual, scientists in both fields face similar challenges. The overlap in source material has prompted periodic discussions and studies on the advantages of collaboration between fields toward mutually beneficial methodological advancements. However, most have been centered around wet laboratory methods (sampling, DNA extraction, library preparation, etc.). In this review, we focus on the computational side of the analytical workflow. We discuss limitations and considerations to consider when working with degraded DNA. We hope this review provides a framework to researchers new to computational workflows for how to think about analyzing highly degraded DNA and prompts an increase of collaboration between the forensic genetics and aDNA fields. |
| first_indexed | 2024-03-11T16:47:26Z |
| format | Article |
| id | doaj.art-a657d5bb23ba47158fecbd9a3a0fb203 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-11T16:47:26Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-a657d5bb23ba47158fecbd9a3a0fb2032023-10-22T04:49:43ZengElsevieriScience2589-00422023-11-012611108066Review: Computational analysis of human skeletal remains in ancient DNA and forensic geneticsAinash Childebayeva0Elena I. Zavala1Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany; Department of Anthropology, University of Kansas, Lawrence, KS, USA; Corresponding authorDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Department of Biology, University of Oregon, Eugene, OR, USASummary: Degraded DNA is used to answer questions in the fields of ancient DNA (aDNA) and forensic genetics. While aDNA studies typically center around human evolution and past history, and forensic genetics is often more concerned with identifying a specific individual, scientists in both fields face similar challenges. The overlap in source material has prompted periodic discussions and studies on the advantages of collaboration between fields toward mutually beneficial methodological advancements. However, most have been centered around wet laboratory methods (sampling, DNA extraction, library preparation, etc.). In this review, we focus on the computational side of the analytical workflow. We discuss limitations and considerations to consider when working with degraded DNA. We hope this review provides a framework to researchers new to computational workflows for how to think about analyzing highly degraded DNA and prompts an increase of collaboration between the forensic genetics and aDNA fields.http://www.sciencedirect.com/science/article/pii/S2589004223021430Molecular biologyComputational bioinformaticsPaleogeneticsArcheology |
| spellingShingle | Ainash Childebayeva Elena I. Zavala Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics iScience Molecular biology Computational bioinformatics Paleogenetics Archeology |
| title | Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics |
| title_full | Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics |
| title_fullStr | Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics |
| title_full_unstemmed | Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics |
| title_short | Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics |
| title_sort | review computational analysis of human skeletal remains in ancient dna and forensic genetics |
| topic | Molecular biology Computational bioinformatics Paleogenetics Archeology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223021430 |
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