Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population
The purpose of this study was to examine differences in risk factors associated with hepatocellular carcinoma (HCC) among White and African Americans from low socioeconomic backgrounds in the Southern Community Cohort Study (SCCS). The SCCS is a prospective cohort study with participants from the so...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/15/3710 |
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| author | Sylvie Muhimpundu Rebecca Baqiyyah N. Conway Shaneda Warren Andersen Loren Lipworth Mark D. Steinwandel William J. Blot Xiao-Ou Shu Staci L. Sudenga |
| author_facet | Sylvie Muhimpundu Rebecca Baqiyyah N. Conway Shaneda Warren Andersen Loren Lipworth Mark D. Steinwandel William J. Blot Xiao-Ou Shu Staci L. Sudenga |
| author_sort | Sylvie Muhimpundu |
| collection | DOAJ |
| description | The purpose of this study was to examine differences in risk factors associated with hepatocellular carcinoma (HCC) among White and African Americans from low socioeconomic backgrounds in the Southern Community Cohort Study (SCCS). The SCCS is a prospective cohort study with participants from the southeastern US. HCC incidence rates were calculated. Multivariable Cox regression was used to calculate HCC-adjusted hazard ratios (aHR) associated with known baseline HCC risk factors for White and African Americans, separately. There were 294 incident HCC. The incidence rate ratio for HCC was higher (IRR = 1.4, 95%CI: 1.1–1.9) in African Americans compared to White Americans. White Americans saw a stronger association between self-reported hepatitis C virus (aHR = 19.24, 95%CI: 10.58–35.00) and diabetes (aHR = 3.55, 95%CI: 1.96–6.43) for the development of HCC compared to African Americans (aHR = 7.73, 95%CI: 5.71–10.47 and aHR = 1.48, 95%CI: 1.06–2.06, respectively) even though the prevalence of these risk factors was similar between races. Smoking (aHR = 2.91, 95%CI: 1.87–4.52) and heavy alcohol consumption (aHR = 1.59, 95%CI: 1.19–2.11) were significantly associated with HCC risk among African Americans only. In this large prospective cohort, we observed racial differences in HCC incidence and risk factors associated with HCC among White and African Americans. |
| first_indexed | 2024-03-10T09:18:05Z |
| format | Article |
| id | doaj.art-a658a41ce9354ed7b2ed4d45488a5e84 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:18:05Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a658a41ce9354ed7b2ed4d45488a5e842023-11-22T05:26:33ZengMDPI AGCancers2072-66942021-07-011315371010.3390/cancers13153710Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic PopulationSylvie Muhimpundu0Rebecca Baqiyyah N. Conway1Shaneda Warren Andersen2Loren Lipworth3Mark D. Steinwandel4William J. Blot5Xiao-Ou Shu6Staci L. Sudenga7Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37232, USASchool of Community and Rural Health, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USADepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USADivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37232, USAInternational Epidemiology Institute, Rockville, MD 20850, USADivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37232, USADivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37232, USADivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37232, USAThe purpose of this study was to examine differences in risk factors associated with hepatocellular carcinoma (HCC) among White and African Americans from low socioeconomic backgrounds in the Southern Community Cohort Study (SCCS). The SCCS is a prospective cohort study with participants from the southeastern US. HCC incidence rates were calculated. Multivariable Cox regression was used to calculate HCC-adjusted hazard ratios (aHR) associated with known baseline HCC risk factors for White and African Americans, separately. There were 294 incident HCC. The incidence rate ratio for HCC was higher (IRR = 1.4, 95%CI: 1.1–1.9) in African Americans compared to White Americans. White Americans saw a stronger association between self-reported hepatitis C virus (aHR = 19.24, 95%CI: 10.58–35.00) and diabetes (aHR = 3.55, 95%CI: 1.96–6.43) for the development of HCC compared to African Americans (aHR = 7.73, 95%CI: 5.71–10.47 and aHR = 1.48, 95%CI: 1.06–2.06, respectively) even though the prevalence of these risk factors was similar between races. Smoking (aHR = 2.91, 95%CI: 1.87–4.52) and heavy alcohol consumption (aHR = 1.59, 95%CI: 1.19–2.11) were significantly associated with HCC risk among African Americans only. In this large prospective cohort, we observed racial differences in HCC incidence and risk factors associated with HCC among White and African Americans.https://www.mdpi.com/2072-6694/13/15/3710cancer risksoutheastracial disparitySCCS |
| spellingShingle | Sylvie Muhimpundu Rebecca Baqiyyah N. Conway Shaneda Warren Andersen Loren Lipworth Mark D. Steinwandel William J. Blot Xiao-Ou Shu Staci L. Sudenga Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population Cancers cancer risk southeast racial disparity SCCS |
| title | Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population |
| title_full | Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population |
| title_fullStr | Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population |
| title_full_unstemmed | Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population |
| title_short | Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population |
| title_sort | racial differences in hepatocellular carcinoma incidence and risk factors among a low socioeconomic population |
| topic | cancer risk southeast racial disparity SCCS |
| url | https://www.mdpi.com/2072-6694/13/15/3710 |
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