Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer’s patches of mice and orients the immune response towards humoral immunity
<p>Abstract</p> <p>The large numbers of human intestinal microorganisms have a highly co-evolved relationship with the immune system. Dysbacteriosis of intestinal microbiota induces alterations of immune responses, and is closely related to disease development. Peyer’s patches are...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-12-01
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| Series: | Gut Pathogens |
| Subjects: | |
| Online Access: | http://www.gutpathogens.com/content/4/1/19 |
| _version_ | 1828432797517217792 |
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| author | Gao Fei Li Ming Liu Yinhui Gao Chuanzhou Wen Shu Tang Li |
| author_facet | Gao Fei Li Ming Liu Yinhui Gao Chuanzhou Wen Shu Tang Li |
| author_sort | Gao Fei |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The large numbers of human intestinal microorganisms have a highly co-evolved relationship with the immune system. Dysbacteriosis of intestinal microbiota induces alterations of immune responses, and is closely related to disease development. Peyer’s patches are immune sensors in intestine which exert essential functions during development of inflammatory disease. However, interactions between commensal bacteria and PPs have been poorly characterized. In this study, changes of lymphocyte subpopulations and production of cytokines in PPs of mice with intestinal dysbacteriosis were investigated. The ceftriaxone-induced dysbacteriosis caused a notable change in populations of T lymphocytes, their subpopulations in PPs and expressions of various cytokines. Our results suggest intestinal dysbacteriosis in mice reduces immune tolerance in PPs and orients immune response towards humoral immunity.</p> |
| first_indexed | 2024-12-10T18:25:55Z |
| format | Article |
| id | doaj.art-a6599997e251441a9b112d8a8f89d891 |
| institution | Directory Open Access Journal |
| issn | 1757-4749 |
| language | English |
| last_indexed | 2024-12-10T18:25:55Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Gut Pathogens |
| spelling | doaj.art-a6599997e251441a9b112d8a8f89d8912022-12-22T01:38:05ZengBMCGut Pathogens1757-47492012-12-01411910.1186/1757-4749-4-19Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer’s patches of mice and orients the immune response towards humoral immunityGao FeiLi MingLiu YinhuiGao ChuanzhouWen ShuTang Li<p>Abstract</p> <p>The large numbers of human intestinal microorganisms have a highly co-evolved relationship with the immune system. Dysbacteriosis of intestinal microbiota induces alterations of immune responses, and is closely related to disease development. Peyer’s patches are immune sensors in intestine which exert essential functions during development of inflammatory disease. However, interactions between commensal bacteria and PPs have been poorly characterized. In this study, changes of lymphocyte subpopulations and production of cytokines in PPs of mice with intestinal dysbacteriosis were investigated. The ceftriaxone-induced dysbacteriosis caused a notable change in populations of T lymphocytes, their subpopulations in PPs and expressions of various cytokines. Our results suggest intestinal dysbacteriosis in mice reduces immune tolerance in PPs and orients immune response towards humoral immunity.</p>http://www.gutpathogens.com/content/4/1/19Intestinal dysbacteriosisPeyer’s patchesImmune responseT lymphocytesCytokines |
| spellingShingle | Gao Fei Li Ming Liu Yinhui Gao Chuanzhou Wen Shu Tang Li Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer’s patches of mice and orients the immune response towards humoral immunity Gut Pathogens Intestinal dysbacteriosis Peyer’s patches Immune response T lymphocytes Cytokines |
| title | Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer’s patches of mice and orients the immune response towards humoral immunity |
| title_full | Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer’s patches of mice and orients the immune response towards humoral immunity |
| title_fullStr | Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer’s patches of mice and orients the immune response towards humoral immunity |
| title_full_unstemmed | Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer’s patches of mice and orients the immune response towards humoral immunity |
| title_short | Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer’s patches of mice and orients the immune response towards humoral immunity |
| title_sort | intestinal dysbacteriosis induces changes of t lymphocyte subpopulations in peyer s patches of mice and orients the immune response towards humoral immunity |
| topic | Intestinal dysbacteriosis Peyer’s patches Immune response T lymphocytes Cytokines |
| url | http://www.gutpathogens.com/content/4/1/19 |
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