Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple Myeloma
The prognosis for newly diagnosed subjects with multiple myeloma (MM) has significantly progressed in recent years. However, most MM patients relapse and after several salvage therapies, the onset of multidrug resistance provokes the occurrence of a refractory disease. A continuous and bidirectional...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/2/448 |
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| author | Alessandro Allegra Roberta Ettari Vanessa Innao Alessandra Bitto |
| author_facet | Alessandro Allegra Roberta Ettari Vanessa Innao Alessandra Bitto |
| author_sort | Alessandro Allegra |
| collection | DOAJ |
| description | The prognosis for newly diagnosed subjects with multiple myeloma (MM) has significantly progressed in recent years. However, most MM patients relapse and after several salvage therapies, the onset of multidrug resistance provokes the occurrence of a refractory disease. A continuous and bidirectional exchange of information takes place between the cells of the microenvironment and neoplastic cells to solicit the demands of cancer cells. Among the molecules serving as messengers, there are microRNAs (miRNA), a family of small noncoding RNAs that regulate gene expression. Numerous miRNAs are associated with drug resistance, also in MM, and the modulation of their expression or activity might be explored to reverse it. In this review we report the most recent studies concerning the relationship between miRNAs and chemoresistance to the most frequently used drugs, such as proteasome inhibitors, steroids, alkylating agents and immunomodulators. The experimental use of antagomirs or miRNA mimics have successfully been proven to counteract chemoresistance and display synergistic effects with antimyeloma drugs which could represent a fundamental moment to overcome resistance in MM treatment. |
| first_indexed | 2024-03-09T00:43:02Z |
| format | Article |
| id | doaj.art-a65a3b2817bb4c18a015873ba0729c13 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T00:43:02Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a65a3b2817bb4c18a015873ba0729c132023-12-11T17:43:03ZengMDPI AGCells2073-44092021-02-0110244810.3390/cells10020448Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple MyelomaAlessandro Allegra0Roberta Ettari1Vanessa Innao2Alessandra Bitto3Department of Human Pathology in Adulthood and Childhood, University of Messina, 98125 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Chemistry, University of Messina, 98100 Messina, ItalyDepartment of Human Pathology in Adulthood and Childhood, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, ItalyThe prognosis for newly diagnosed subjects with multiple myeloma (MM) has significantly progressed in recent years. However, most MM patients relapse and after several salvage therapies, the onset of multidrug resistance provokes the occurrence of a refractory disease. A continuous and bidirectional exchange of information takes place between the cells of the microenvironment and neoplastic cells to solicit the demands of cancer cells. Among the molecules serving as messengers, there are microRNAs (miRNA), a family of small noncoding RNAs that regulate gene expression. Numerous miRNAs are associated with drug resistance, also in MM, and the modulation of their expression or activity might be explored to reverse it. In this review we report the most recent studies concerning the relationship between miRNAs and chemoresistance to the most frequently used drugs, such as proteasome inhibitors, steroids, alkylating agents and immunomodulators. The experimental use of antagomirs or miRNA mimics have successfully been proven to counteract chemoresistance and display synergistic effects with antimyeloma drugs which could represent a fundamental moment to overcome resistance in MM treatment.https://www.mdpi.com/2073-4409/10/2/448micro-RNAmultiple myelomachemoresistancebone marrow microenvironmentantagomirmiRNA mimics |
| spellingShingle | Alessandro Allegra Roberta Ettari Vanessa Innao Alessandra Bitto Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple Myeloma Cells micro-RNA multiple myeloma chemoresistance bone marrow microenvironment antagomir miRNA mimics |
| title | Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple Myeloma |
| title_full | Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple Myeloma |
| title_fullStr | Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple Myeloma |
| title_full_unstemmed | Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple Myeloma |
| title_short | Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple Myeloma |
| title_sort | potential role of micrornas in inducing drug resistance in patients with multiple myeloma |
| topic | micro-RNA multiple myeloma chemoresistance bone marrow microenvironment antagomir miRNA mimics |
| url | https://www.mdpi.com/2073-4409/10/2/448 |
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