Total marrow irradiation reduces organ damage and enhances tissue repair with the potential to increase the targeted dose of bone marrow in both young and old mice

Total marrow irradiation reduces organ damage and enhances tissue repair with the potential to increase the targeted dose of bone marrow in both young and old mice

Total body irradiation (TBI) is a commonly used conditioning regimen for hematopoietic stem cell transplant (HCT), but dose heterogeneity and long-term organ toxicity pose significant challenges. Total marrow irradiation (TMI), an evolving radiation conditioning regimen for HCT can overcome the limi...

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Bibliographic Details
Main Authors: Ji Eun Lim, Srideshikan Sargur Madabushi, Paresh Vishwasrao, Joo Y. Song, Amr M. H. Abdelhamid, Hemendra Ghimire, V. L. Vanishree, Jatinder K. Lamba, Savita Dandapani, Amandeep Salhotra, Mengistu Lemecha, Antonio Pierini, Daohong Zhao, Guy Storme, Shernan Holtan, Cynthia Aristei, Dorthe Schaue, Monzr Al Malki, Susanta K. Hui
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
total marrow irradiation
bone marrow transplantation
aging
tissue damage
tissue repair
DNA damage
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1045016/full

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