The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia
Poststroke aphasia is one of the most dramatic functional deficits that results from direct damage of focal brain regions and dysfunction of large-scale brain networks. The reconstruction of language function depends on the hierarchical whole-brain dynamic reorganization. However, investigations int...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222002558 |
| _version_ | 1811258553781977088 |
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| author | Liming Fan Chenxi Li Zi-gang Huang Jie Zhao Xiaofeng Wu Tian Liu Youjun Li Jue Wang |
| author_facet | Liming Fan Chenxi Li Zi-gang Huang Jie Zhao Xiaofeng Wu Tian Liu Youjun Li Jue Wang |
| author_sort | Liming Fan |
| collection | DOAJ |
| description | Poststroke aphasia is one of the most dramatic functional deficits that results from direct damage of focal brain regions and dysfunction of large-scale brain networks. The reconstruction of language function depends on the hierarchical whole-brain dynamic reorganization. However, investigations into the longitudinal neural changes of large-scale brain networks for poststroke aphasia remain scarce. Here we characterize large-scale brain dynamics in left-frontal-stroke aphasia through energy landscape analysis. Using fMRI during an auditory comprehension task, we find that aphasia patients suffer serious whole-brain dynamics perturbation in the acute and subacute stages after stroke, in which the brains were restricted into two major activity patterns. Following spontaneous recovery process, the brain flexibility improved in the chronic stage. Critically, we demonstrated that the abnormal neural dynamics are correlated with the aberrant brain network coordination. Taken together, the energy landscape analysis exhibited that the acute poststroke aphasia has a constrained, low dimensional brain dynamics, which were replaced by less constrained and high dimensional dynamics at chronic aphasia. Our study provides a new perspective to profoundly understand the pathological mechanisms of poststroke aphasia. |
| first_indexed | 2024-04-12T18:16:12Z |
| format | Article |
| id | doaj.art-a65ee19786ca4ea1948e38a59b702e27 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-12T18:16:12Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-a65ee19786ca4ea1948e38a59b702e272022-12-22T03:21:37ZengElsevierNeuroImage: Clinical2213-15822022-01-0136103190The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasiaLiming Fan0Chenxi Li1Zi-gang Huang2Jie Zhao3Xiaofeng Wu4Tian Liu5Youjun Li6Jue Wang7The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, PR China; National Engineering Research Center of Health Care and Medical Devices. Guangzhou, Guangdong 510500, PR ChinaDepartment of the Psychology of Military Medicine, Air Force Medical University, Xi’an, Shaanxi 710032, PR ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, PR China; National Engineering Research Center of Health Care and Medical Devices. Guangzhou, Guangdong 510500, PR ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, PR China; National Engineering Research Center of Health Care and Medical Devices. Guangzhou, Guangdong 510500, PR ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, PR China; National Engineering Research Center of Health Care and Medical Devices. Guangzhou, Guangdong 510500, PR ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, PR China; National Engineering Research Center of Health Care and Medical Devices. Guangzhou, Guangdong 510500, PR ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, PR China; National Engineering Research Center of Health Care and Medical Devices. Guangzhou, Guangdong 510500, PR China; Corresponding authors at: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, PR China.The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, PR China; National Engineering Research Center of Health Care and Medical Devices. Guangzhou, Guangdong 510500, PR China; The Key Laboratory of Neuro-informatics & Rehabilitation Engineering of Ministry of Civil Affairs, Xi’an, Shaanxi 710049, PR China; Corresponding authors at: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, PR China.Poststroke aphasia is one of the most dramatic functional deficits that results from direct damage of focal brain regions and dysfunction of large-scale brain networks. The reconstruction of language function depends on the hierarchical whole-brain dynamic reorganization. However, investigations into the longitudinal neural changes of large-scale brain networks for poststroke aphasia remain scarce. Here we characterize large-scale brain dynamics in left-frontal-stroke aphasia through energy landscape analysis. Using fMRI during an auditory comprehension task, we find that aphasia patients suffer serious whole-brain dynamics perturbation in the acute and subacute stages after stroke, in which the brains were restricted into two major activity patterns. Following spontaneous recovery process, the brain flexibility improved in the chronic stage. Critically, we demonstrated that the abnormal neural dynamics are correlated with the aberrant brain network coordination. Taken together, the energy landscape analysis exhibited that the acute poststroke aphasia has a constrained, low dimensional brain dynamics, which were replaced by less constrained and high dimensional dynamics at chronic aphasia. Our study provides a new perspective to profoundly understand the pathological mechanisms of poststroke aphasia.http://www.sciencedirect.com/science/article/pii/S2213158222002558Post-stroke aphasiafMRIEnergy landscapeMajor statesBrain flexibility |
| spellingShingle | Liming Fan Chenxi Li Zi-gang Huang Jie Zhao Xiaofeng Wu Tian Liu Youjun Li Jue Wang The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia NeuroImage: Clinical Post-stroke aphasia fMRI Energy landscape Major states Brain flexibility |
| title | The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia |
| title_full | The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia |
| title_fullStr | The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia |
| title_full_unstemmed | The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia |
| title_short | The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia |
| title_sort | longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasia |
| topic | Post-stroke aphasia fMRI Energy landscape Major states Brain flexibility |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222002558 |
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