Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions

Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions

Ischemic tissues accumulate succinate, which is rapidly oxidized upon reperfusion, driving a burst of mitochondrial reactive oxygen species (ROS) generation that triggers cell death. In isolated mitochondria with succinate as the sole metabolic substrate under non-phosphorylating conditions, 90 % of...

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Bibliographic Details
Main Authors: Caio Tabata Fukushima, Ian-Shika Dancil, Hannah Clary, Nidhi Shah, Sergiy M. Nadtochiy, Paul S. Brookes
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
Mitochondria
Ischemia
Reperfusion
Complex-I
Reverse electron transfer
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000235

Internet

http://www.sciencedirect.com/science/article/pii/S2213231724000235

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