Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions
Ischemic tissues accumulate succinate, which is rapidly oxidized upon reperfusion, driving a burst of mitochondrial reactive oxygen species (ROS) generation that triggers cell death. In isolated mitochondria with succinate as the sole metabolic substrate under non-phosphorylating conditions, 90 % of...
Main Authors: | Caio Tabata Fukushima, Ian-Shika Dancil, Hannah Clary, Nidhi Shah, Sergiy M. Nadtochiy, Paul S. Brookes |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2024-04-01
|
Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231724000235 |
Similar Items
-
Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation
by: Alexander S. Milliken, et al.
Published: (2022-07-01) -
The Alterations in Mitochondrial Dynamics Following Cerebral Ischemia/Reperfusion Injury
by: Jirapong Vongsfak, et al.
Published: (2021-08-01) -
Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury
by: Ivo F. Machado, et al.
Published: (2023-03-01) -
The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury
by: Jie Huang, et al.
Published: (2023-06-01) -
Pharmaceutical Manipulation of Mitochondrial F0F1‐ATP Synthase Enables Imaging and Protection of Myocardial Ischemia/Reperfusion Injury Through Stress‐induced Selective Enrichment
by: Zelin Chen, et al.
Published: (2024-03-01)