Antibacterial effects of a new triterpenoid saponin from roots of Gardenia ternifolia Schumach. & Thonn (Rubiaceae)
A new triterpenoid saponin was isolated from Gardenia ternifolia Schumach. & Thonn (Rubiaceae), Ternifoliaoside A 1 together with 8 known compounds 2–9 β-sitosterol, β-Stigmasterol-glucoside, 3β,23,24–trihydroxyurs-12-en-28-oic acid, 3β,19 α,23,24–tetrahydroxyurs-12-en-28-oic acid, lippianos...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
|
| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622000856 |
| _version_ | 1798005911970643968 |
|---|---|
| author | Dabolé Bernard Yaya Hassana Moussa Djaouda Matcheme Mathieu Wakayansam Bouba Romeo Koubala Benoît Atia Tul Wahab |
| author_facet | Dabolé Bernard Yaya Hassana Moussa Djaouda Matcheme Mathieu Wakayansam Bouba Romeo Koubala Benoît Atia Tul Wahab |
| author_sort | Dabolé Bernard |
| collection | DOAJ |
| description | A new triterpenoid saponin was isolated from Gardenia ternifolia Schumach. & Thonn (Rubiaceae), Ternifoliaoside A 1 together with 8 known compounds 2–9 β-sitosterol, β-Stigmasterol-glucoside, 3β,23,24–trihydroxyurs-12-en-28-oic acid, 3β,19 α,23,24–tetrahydroxyurs-12-en-28-oic acid, lippianoside B, silphioside F, copteroside B and 24(24′)[Z]-dehydroamarasterone B were isolated from the roots of Gardenia ternifolia Schumach. &Thonn. Compound 1 which is a saponin was reported for the first time in the Gardenia ternifolia species. Their structures were elucidated by analysis of 1D and 2D-NMR studies as well as ESI-MS and HR-FAB-MS. Evaluation of the antibacterial activities of compounds 1, 2, 5, and 9 were performed by the Muller-Hinton agar diffusion method. The microorganisms used were Escherichia coli, Salmonella typhi (Enterobacteriaceae), staphilococus aureaus psodomonase aerogenosae and Vibrion cholorae. No effect was shown on S. aureus, S. typhi, V. cholerae and E. coli with compounds 2 and 9 at different doses: 45 mg/mL, 35 mg/mL, 25 mg/mL and 15 ml/mL. At the highest concentration of 25 mg/ml, compound 5 exhibits the effect on Pseudomonas aeruginosa and Staphylococcus aureus to a diameter of 15.6 ± 2 mm (Pseudomonas aeruginosa) and 12.2 ± 2 mm (Staphylococcus aureus). Compound 1 shows very sensitive effect on a Salmonnela typhi and the E. coli strains, respectively at an inhibition diameter of 20.1 ± 2 mm and 15.40 ± 2 mm at a concentration of 25 mg/ml. |
| first_indexed | 2024-04-11T12:47:39Z |
| format | Article |
| id | doaj.art-a661ed67fee04d3497c8416a67bea1b6 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-11T12:47:39Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-a661ed67fee04d3497c8416a67bea1b62022-12-22T04:23:19ZengElsevierResults in Chemistry2211-71562022-01-014100366Antibacterial effects of a new triterpenoid saponin from roots of Gardenia ternifolia Schumach. & Thonn (Rubiaceae)Dabolé Bernard0Yaya Hassana1Moussa Djaouda2Matcheme Mathieu3Wakayansam Bouba Romeo4Koubala Benoît5Atia Tul Wahab6Department of Chemistry, Faculty of Science, University of Maroua, Cameroon; Department of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, University of Maroua, Cameroon; Corresponding author at: Department of Chemistry, Faculty of Science, University of Maroua, Cameroon.Department of Chemistry, Faculty of Science, University of Maroua, CameroonDepartment of Life and Earth Sciences, Higher Teachers’ Training College, University of Maroua, CameroonDepartment of Chemistry, Faculty of Science, University of Maroua, CameroonDepartment of Biological Sciences, Faculty of Science, University of Maroua, CameroonDepartment of Chemistry, Faculty of Science, University of Maroua, Cameroon; Department of Life and Earth Sciences, Higher Teachers’ Training College, University of Maroua, CameroonInternational Center for Chemical and Biological Sciences, University of Karachi, Karachi, PakistanA new triterpenoid saponin was isolated from Gardenia ternifolia Schumach. & Thonn (Rubiaceae), Ternifoliaoside A 1 together with 8 known compounds 2–9 β-sitosterol, β-Stigmasterol-glucoside, 3β,23,24–trihydroxyurs-12-en-28-oic acid, 3β,19 α,23,24–tetrahydroxyurs-12-en-28-oic acid, lippianoside B, silphioside F, copteroside B and 24(24′)[Z]-dehydroamarasterone B were isolated from the roots of Gardenia ternifolia Schumach. &Thonn. Compound 1 which is a saponin was reported for the first time in the Gardenia ternifolia species. Their structures were elucidated by analysis of 1D and 2D-NMR studies as well as ESI-MS and HR-FAB-MS. Evaluation of the antibacterial activities of compounds 1, 2, 5, and 9 were performed by the Muller-Hinton agar diffusion method. The microorganisms used were Escherichia coli, Salmonella typhi (Enterobacteriaceae), staphilococus aureaus psodomonase aerogenosae and Vibrion cholorae. No effect was shown on S. aureus, S. typhi, V. cholerae and E. coli with compounds 2 and 9 at different doses: 45 mg/mL, 35 mg/mL, 25 mg/mL and 15 ml/mL. At the highest concentration of 25 mg/ml, compound 5 exhibits the effect on Pseudomonas aeruginosa and Staphylococcus aureus to a diameter of 15.6 ± 2 mm (Pseudomonas aeruginosa) and 12.2 ± 2 mm (Staphylococcus aureus). Compound 1 shows very sensitive effect on a Salmonnela typhi and the E. coli strains, respectively at an inhibition diameter of 20.1 ± 2 mm and 15.40 ± 2 mm at a concentration of 25 mg/ml.http://www.sciencedirect.com/science/article/pii/S2211715622000856Triterpenoid saponinRootsGardenia ternifolia Schumach. & ThonnTernifoliaoside AAntibacterial |
| spellingShingle | Dabolé Bernard Yaya Hassana Moussa Djaouda Matcheme Mathieu Wakayansam Bouba Romeo Koubala Benoît Atia Tul Wahab Antibacterial effects of a new triterpenoid saponin from roots of Gardenia ternifolia Schumach. & Thonn (Rubiaceae) Results in Chemistry Triterpenoid saponin Roots Gardenia ternifolia Schumach. & Thonn Ternifoliaoside A Antibacterial |
| title | Antibacterial effects of a new triterpenoid saponin from roots of Gardenia ternifolia Schumach. & Thonn (Rubiaceae) |
| title_full | Antibacterial effects of a new triterpenoid saponin from roots of Gardenia ternifolia Schumach. & Thonn (Rubiaceae) |
| title_fullStr | Antibacterial effects of a new triterpenoid saponin from roots of Gardenia ternifolia Schumach. & Thonn (Rubiaceae) |
| title_full_unstemmed | Antibacterial effects of a new triterpenoid saponin from roots of Gardenia ternifolia Schumach. & Thonn (Rubiaceae) |
| title_short | Antibacterial effects of a new triterpenoid saponin from roots of Gardenia ternifolia Schumach. & Thonn (Rubiaceae) |
| title_sort | antibacterial effects of a new triterpenoid saponin from roots of gardenia ternifolia schumach amp thonn rubiaceae |
| topic | Triterpenoid saponin Roots Gardenia ternifolia Schumach. & Thonn Ternifoliaoside A Antibacterial |
| url | http://www.sciencedirect.com/science/article/pii/S2211715622000856 |
| work_keys_str_mv | AT dabolebernard antibacterialeffectsofanewtriterpenoidsaponinfromrootsofgardeniaternifoliaschumachampthonnrubiaceae AT yayahassana antibacterialeffectsofanewtriterpenoidsaponinfromrootsofgardeniaternifoliaschumachampthonnrubiaceae AT moussadjaouda antibacterialeffectsofanewtriterpenoidsaponinfromrootsofgardeniaternifoliaschumachampthonnrubiaceae AT matchememathieu antibacterialeffectsofanewtriterpenoidsaponinfromrootsofgardeniaternifoliaschumachampthonnrubiaceae AT wakayansamboubaromeo antibacterialeffectsofanewtriterpenoidsaponinfromrootsofgardeniaternifoliaschumachampthonnrubiaceae AT koubalabenoit antibacterialeffectsofanewtriterpenoidsaponinfromrootsofgardeniaternifoliaschumachampthonnrubiaceae AT atiatulwahab antibacterialeffectsofanewtriterpenoidsaponinfromrootsofgardeniaternifoliaschumachampthonnrubiaceae |