Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide
Fungi are reported to cause a range of superficial to invasive human infections. These often result in high morbidity and at times mortality. Conventional antifungal agents though effective invariably exhibit drug interactions, treatment-related toxicity, and fail to elicit significant effect, thus...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/12/1070 |
| _version_ | 1797503200437207040 |
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| author | Pratibha Sharma Mehak Chaudhary Garima Khanna Praveen Rishi Indu Pal Kaur |
| author_facet | Pratibha Sharma Mehak Chaudhary Garima Khanna Praveen Rishi Indu Pal Kaur |
| author_sort | Pratibha Sharma |
| collection | DOAJ |
| description | Fungi are reported to cause a range of superficial to invasive human infections. These often result in high morbidity and at times mortality. Conventional antifungal agents though effective invariably exhibit drug interactions, treatment-related toxicity, and fail to elicit significant effect, thus indicating a need to look for suitable alternatives. Fungi thrive in humid, nutrient-enriched areas. Such an environment is well-supported by the oral cavity. Despite this, there is a relatively low incidence of severe oral and periodontal fungal infections, attributed to the presence of antimicrobial peptides hosted by saliva, viz. histatin 5 (Hstn 5). It displays fungicidal activity against a variety of fungi including <i>Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans</i>, and unicellular yeast-like <i>Saccharomyces cerevisiae</i>. <i>Candida albicans</i> alone accounts for about 70% of all global fungal infections including periodontal disease. This review intends to discuss the scope of Hstn 5 as a novel recourse for the control of fungal infections. |
| first_indexed | 2024-03-10T03:47:08Z |
| format | Article |
| id | doaj.art-a6637a5ce6764ec28bfaed066eea9548 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T03:47:08Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-a6637a5ce6764ec28bfaed066eea95482023-11-23T09:05:24ZengMDPI AGJournal of Fungi2309-608X2021-12-01712107010.3390/jof7121070Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary PeptidePratibha Sharma0Mehak Chaudhary1Garima Khanna2Praveen Rishi3Indu Pal Kaur4University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaDepartment of Microbiology, Panjab University, Chandigarh 160014, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaFungi are reported to cause a range of superficial to invasive human infections. These often result in high morbidity and at times mortality. Conventional antifungal agents though effective invariably exhibit drug interactions, treatment-related toxicity, and fail to elicit significant effect, thus indicating a need to look for suitable alternatives. Fungi thrive in humid, nutrient-enriched areas. Such an environment is well-supported by the oral cavity. Despite this, there is a relatively low incidence of severe oral and periodontal fungal infections, attributed to the presence of antimicrobial peptides hosted by saliva, viz. histatin 5 (Hstn 5). It displays fungicidal activity against a variety of fungi including <i>Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans</i>, and unicellular yeast-like <i>Saccharomyces cerevisiae</i>. <i>Candida albicans</i> alone accounts for about 70% of all global fungal infections including periodontal disease. This review intends to discuss the scope of Hstn 5 as a novel recourse for the control of fungal infections.https://www.mdpi.com/2309-608X/7/12/1070fungihistatin 5candidiasis<i>Candida</i>periodontaloral cavity |
| spellingShingle | Pratibha Sharma Mehak Chaudhary Garima Khanna Praveen Rishi Indu Pal Kaur Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide Journal of Fungi fungi histatin 5 candidiasis <i>Candida</i> periodontal oral cavity |
| title | Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide |
| title_full | Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide |
| title_fullStr | Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide |
| title_full_unstemmed | Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide |
| title_short | Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide |
| title_sort | envisaging antifungal potential of histatin 5 a physiological salivary peptide |
| topic | fungi histatin 5 candidiasis <i>Candida</i> periodontal oral cavity |
| url | https://www.mdpi.com/2309-608X/7/12/1070 |
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