Changes in optimal stimulation frequency with time for gait disturbances in patients with PD after STN-DBS—A longitudinal study
Aim: To assess the changes in frequency parameters of STN-DBS stimulation over 6 months required to optimize gait in PD patients. Methods: It's a single center, open label longitudinal study of PD patients after STN-DBS with gait disorders. Gait assessment using stand–walk–sit (SWS) test and fr...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2023;volume=26;issue=4;spage=401;epage=407;aulast=Kola |
| _version_ | 1797649518620049408 |
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| author | Sruthi Kola Ravi Prakash Rangam Rukmini M Kandadai Rajesh Alugolu Raghuram Kedasi Pavan Swamygowda VVSRK Prasad Sai Sri Lakshmi Meka Syed T Fathima Rupam Borgohain |
| author_facet | Sruthi Kola Ravi Prakash Rangam Rukmini M Kandadai Rajesh Alugolu Raghuram Kedasi Pavan Swamygowda VVSRK Prasad Sai Sri Lakshmi Meka Syed T Fathima Rupam Borgohain |
| author_sort | Sruthi Kola |
| collection | DOAJ |
| description | Aim: To assess the changes in frequency parameters of STN-DBS stimulation over 6 months required to optimize gait in PD patients. Methods: It's a single center, open label longitudinal study of PD patients after STN-DBS with gait disorders. Gait assessment using stand–walk–sit (SWS) test and freezing of gait (FOG) scores were done at baseline and after 6 months. Gait was assessed in five frequencies settings, that is, 60 Hz, 90 Hz, 130 Hz, 180 Hz and stimulation “OFF” during medication ON state. Voltage was maintained. Results: Fifteen post-deep brain stimulation (DBS) patients were included. Mean duration after surgery was 3.73 ± 2.82 years. In SWS and FOG at baseline, five patients have good response at 180 Hz frequency, five at 130 Hz, one at 90 Hz, two patients at 60 Hz, one both 60 and 90 Hz, and one at both 90 and 180 HZ. And after 6 months out of the 13 patients who were able to perform the test, four patients had good response at 180 Hz frequency, four at 130 Hz, two at 90 Hz, one each for 60 Hz and battery OFF state, and one for both 130 Hz and 180 Hz. At 6 months, four patients had good response at the same frequency as baseline, while 11 patients have change in frequency from baseline. Conclusion: Optimal frequency for gait varies in patients—both low and high frequency may be useful. Optimal frequency for improving gait changes over period of time. Regular assessment and changing frequency may improve gait after DBS. |
| first_indexed | 2024-03-11T15:48:15Z |
| format | Article |
| id | doaj.art-a664db9982c847a0819843882fe79cb7 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-03-11T15:48:15Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-a664db9982c847a0819843882fe79cb72023-10-26T05:44:41ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492023-01-0126440140710.4103/aian.aian_95_23Changes in optimal stimulation frequency with time for gait disturbances in patients with PD after STN-DBS—A longitudinal studySruthi KolaRavi Prakash RangamRukmini M KandadaiRajesh AlugoluRaghuram KedasiPavan SwamygowdaVVSRK PrasadSai Sri Lakshmi MekaSyed T FathimaRupam BorgohainAim: To assess the changes in frequency parameters of STN-DBS stimulation over 6 months required to optimize gait in PD patients. Methods: It's a single center, open label longitudinal study of PD patients after STN-DBS with gait disorders. Gait assessment using stand–walk–sit (SWS) test and freezing of gait (FOG) scores were done at baseline and after 6 months. Gait was assessed in five frequencies settings, that is, 60 Hz, 90 Hz, 130 Hz, 180 Hz and stimulation “OFF” during medication ON state. Voltage was maintained. Results: Fifteen post-deep brain stimulation (DBS) patients were included. Mean duration after surgery was 3.73 ± 2.82 years. In SWS and FOG at baseline, five patients have good response at 180 Hz frequency, five at 130 Hz, one at 90 Hz, two patients at 60 Hz, one both 60 and 90 Hz, and one at both 90 and 180 HZ. And after 6 months out of the 13 patients who were able to perform the test, four patients had good response at 180 Hz frequency, four at 130 Hz, two at 90 Hz, one each for 60 Hz and battery OFF state, and one for both 130 Hz and 180 Hz. At 6 months, four patients had good response at the same frequency as baseline, while 11 patients have change in frequency from baseline. Conclusion: Optimal frequency for gait varies in patients—both low and high frequency may be useful. Optimal frequency for improving gait changes over period of time. Regular assessment and changing frequency may improve gait after DBS.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2023;volume=26;issue=4;spage=401;epage=407;aulast=Koladeep brain stimulationfrequencygaitsubthalamic nucleus stimulation |
| spellingShingle | Sruthi Kola Ravi Prakash Rangam Rukmini M Kandadai Rajesh Alugolu Raghuram Kedasi Pavan Swamygowda VVSRK Prasad Sai Sri Lakshmi Meka Syed T Fathima Rupam Borgohain Changes in optimal stimulation frequency with time for gait disturbances in patients with PD after STN-DBS—A longitudinal study Annals of Indian Academy of Neurology deep brain stimulation frequency gait subthalamic nucleus stimulation |
| title | Changes in optimal stimulation frequency with time for gait disturbances in patients with PD after STN-DBS—A longitudinal study |
| title_full | Changes in optimal stimulation frequency with time for gait disturbances in patients with PD after STN-DBS—A longitudinal study |
| title_fullStr | Changes in optimal stimulation frequency with time for gait disturbances in patients with PD after STN-DBS—A longitudinal study |
| title_full_unstemmed | Changes in optimal stimulation frequency with time for gait disturbances in patients with PD after STN-DBS—A longitudinal study |
| title_short | Changes in optimal stimulation frequency with time for gait disturbances in patients with PD after STN-DBS—A longitudinal study |
| title_sort | changes in optimal stimulation frequency with time for gait disturbances in patients with pd after stn dbs a longitudinal study |
| topic | deep brain stimulation frequency gait subthalamic nucleus stimulation |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2023;volume=26;issue=4;spage=401;epage=407;aulast=Kola |
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