Right- and left-sided colon cancer – clinical and pathological differences of the disease entity in one organ
Introduction: Some researchers suggest that cancers located in the right vs. the left side of the colon are different and they can be regarded as distinct disease entities. The aim of this study was to analyze differences in clinical, epidemiological and pathological features of patients with righ...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2016-03-01
|
| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Right-and-left-sided-colon-cancer-clinical-and-pathological-differences-of-the-disease-entity-in-one-organ,19,27133,1,1.html |
| _version_ | 1818270291007111168 |
|---|---|
| author | Michal Mik Maciej Berut Lukasz Dziki Radzislaw Trzcinski Adam Dziki |
| author_facet | Michal Mik Maciej Berut Lukasz Dziki Radzislaw Trzcinski Adam Dziki |
| author_sort | Michal Mik |
| collection | DOAJ |
| description | Introduction: Some researchers suggest that cancers located in the right vs. the left side of the colon are different and they can be regarded as distinct disease entities. The aim of this study was to analyze differences in clinical, epidemiological and pathological features of patients with right-sided (RCC) and left-sided (LCC) colon cancer.
Material and methods : One thousand two hundred and twenty-four patients were operated on due to colorectal cancer. A group of 477 patients (254 women, mean age 65.5 ±11 for the whole group) with colon cancer was included (212 RCC vs. 265 LCC).
Results : Right colon cancer patients were older (67.8 ±11.3 vs. 63.2 ±11.2; p = 0.0087). Left colon cancer patients underwent surgery for urgent indications more often (17.0% vs. 8.5%; p = 0006). Tumor diameter was greater in the RCC group (55 ±60 mm vs. 38 ±21 mm; p = 0.0003). Total number of removed lymph nodes was higher in the RCC group (11.7 ±6 vs. 8.3 ±5; p = 0.0001). Lymph node ratio was higher in the LCC group (0.45 ±0.28 vs. 0.30 ±0.25; p = 0.0063). We found a strong positive correlation between tumor diameter and the number of removed lymph nodes in the LCC group (r = 0.531).
Conclusions : These differences may result from the fact that RCC patients are diagnosed at an older age. The smaller number of removed lymph nodes in LCC patients may result in incorrect staging. It is still necessary to find other biological dissimilarities of adenocarcinoma located on different sides of the colon. |
| first_indexed | 2024-12-12T21:07:56Z |
| format | Article |
| id | doaj.art-a6653f7fd303428b83dd2fddee90cb0a |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-12-12T21:07:56Z |
| publishDate | 2016-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-a6653f7fd303428b83dd2fddee90cb0a2022-12-22T00:11:59ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512016-03-0113115716210.5114/aoms.2016.5859627133Right- and left-sided colon cancer – clinical and pathological differences of the disease entity in one organMichal MikMaciej BerutLukasz DzikiRadzislaw TrzcinskiAdam DzikiIntroduction: Some researchers suggest that cancers located in the right vs. the left side of the colon are different and they can be regarded as distinct disease entities. The aim of this study was to analyze differences in clinical, epidemiological and pathological features of patients with right-sided (RCC) and left-sided (LCC) colon cancer. Material and methods : One thousand two hundred and twenty-four patients were operated on due to colorectal cancer. A group of 477 patients (254 women, mean age 65.5 ±11 for the whole group) with colon cancer was included (212 RCC vs. 265 LCC). Results : Right colon cancer patients were older (67.8 ±11.3 vs. 63.2 ±11.2; p = 0.0087). Left colon cancer patients underwent surgery for urgent indications more often (17.0% vs. 8.5%; p = 0006). Tumor diameter was greater in the RCC group (55 ±60 mm vs. 38 ±21 mm; p = 0.0003). Total number of removed lymph nodes was higher in the RCC group (11.7 ±6 vs. 8.3 ±5; p = 0.0001). Lymph node ratio was higher in the LCC group (0.45 ±0.28 vs. 0.30 ±0.25; p = 0.0063). We found a strong positive correlation between tumor diameter and the number of removed lymph nodes in the LCC group (r = 0.531). Conclusions : These differences may result from the fact that RCC patients are diagnosed at an older age. The smaller number of removed lymph nodes in LCC patients may result in incorrect staging. It is still necessary to find other biological dissimilarities of adenocarcinoma located on different sides of the colon.https://www.termedia.pl/Right-and-left-sided-colon-cancer-clinical-and-pathological-differences-of-the-disease-entity-in-one-organ,19,27133,1,1.htmlcolon cancer pathology surgery location right-sided left-sided |
| spellingShingle | Michal Mik Maciej Berut Lukasz Dziki Radzislaw Trzcinski Adam Dziki Right- and left-sided colon cancer – clinical and pathological differences of the disease entity in one organ Archives of Medical Science colon cancer pathology surgery location right-sided left-sided |
| title | Right- and left-sided colon cancer – clinical and pathological differences of the disease entity in one organ |
| title_full | Right- and left-sided colon cancer – clinical and pathological differences of the disease entity in one organ |
| title_fullStr | Right- and left-sided colon cancer – clinical and pathological differences of the disease entity in one organ |
| title_full_unstemmed | Right- and left-sided colon cancer – clinical and pathological differences of the disease entity in one organ |
| title_short | Right- and left-sided colon cancer – clinical and pathological differences of the disease entity in one organ |
| title_sort | right and left sided colon cancer clinical and pathological differences of the disease entity in one organ |
| topic | colon cancer pathology surgery location right-sided left-sided |
| url | https://www.termedia.pl/Right-and-left-sided-colon-cancer-clinical-and-pathological-differences-of-the-disease-entity-in-one-organ,19,27133,1,1.html |
| work_keys_str_mv | AT michalmik rightandleftsidedcoloncancerclinicalandpathologicaldifferencesofthediseaseentityinoneorgan AT maciejberut rightandleftsidedcoloncancerclinicalandpathologicaldifferencesofthediseaseentityinoneorgan AT lukaszdziki rightandleftsidedcoloncancerclinicalandpathologicaldifferencesofthediseaseentityinoneorgan AT radzislawtrzcinski rightandleftsidedcoloncancerclinicalandpathologicaldifferencesofthediseaseentityinoneorgan AT adamdziki rightandleftsidedcoloncancerclinicalandpathologicaldifferencesofthediseaseentityinoneorgan |