Should tumor depth be included in prognostication of soft tissue sarcoma?
<p>Abstract</p> <p>Background</p> <p>Most staging systems for soft tissue sarcoma are based on histologic malignancy-grade, tumor size and tumor depth. These factors are generally dichotomized, size at 5 cm. We believe it is unlikely that tumor depth <it>per se &l...
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| Format: | Article |
| Language: | English |
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BMC
2003-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://www.biomedcentral.com/1471-2407/3/17 |
| _version_ | 1831537716994506752 |
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| author | Gustafson Pelle Rydholm Anders |
| author_facet | Gustafson Pelle Rydholm Anders |
| author_sort | Gustafson Pelle |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Most staging systems for soft tissue sarcoma are based on histologic malignancy-grade, tumor size and tumor depth. These factors are generally dichotomized, size at 5 cm. We believe it is unlikely that tumor depth <it>per se </it>should influence a tumor's metastatic capability. Therefore we hypothesized that the unfavourable prognostic importance of depth could be explained by the close association between size and depth, deep-seated tumors on average being larger than the superficial ones. When tumor size is dichotomized, this effect should be most pronounced in the large size (>5 cm) group in which the size span is larger.</p> <p>Methods</p> <p>We analyzed the associations between tumor size and depth and the prognostic importance of grade, size and depth in a population-based series of 490 adult patients with soft tissue sarcoma of the extremity or trunk wall with complete, 4.5 years minimum, follow-up.</p> <p>Results</p> <p>Multivariate analysis showed no major prognostic effect of tumor depth when grade and size were taken into account. The mean size of small tumors was the same whether superficial or deep but the mean size of large and deep-seated tumors were one third larger than that of large but superficial tumors. Tumor depth influenced the prognosis in the subset of high-grade and large tumors. In this subset deep-seated tumors had poorer survival rate than superficial tumors, which could be explained by the larger mean size of the deep-seated tumors.</p> <p>Conclusion</p> <p>Most of the prognostic value of tumor depth in soft tissue sarcomas of the extremity or trunk wall can be explained by the association between tumor size and depth.</p> |
| first_indexed | 2024-12-16T23:11:15Z |
| format | Article |
| id | doaj.art-a665df15d36e4a26a0d1623c7541fb6f |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-16T23:11:15Z |
| publishDate | 2003-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-a665df15d36e4a26a0d1623c7541fb6f2022-12-21T22:12:24ZengBMCBMC Cancer1471-24072003-05-01311710.1186/1471-2407-3-17Should tumor depth be included in prognostication of soft tissue sarcoma?Gustafson PelleRydholm Anders<p>Abstract</p> <p>Background</p> <p>Most staging systems for soft tissue sarcoma are based on histologic malignancy-grade, tumor size and tumor depth. These factors are generally dichotomized, size at 5 cm. We believe it is unlikely that tumor depth <it>per se </it>should influence a tumor's metastatic capability. Therefore we hypothesized that the unfavourable prognostic importance of depth could be explained by the close association between size and depth, deep-seated tumors on average being larger than the superficial ones. When tumor size is dichotomized, this effect should be most pronounced in the large size (>5 cm) group in which the size span is larger.</p> <p>Methods</p> <p>We analyzed the associations between tumor size and depth and the prognostic importance of grade, size and depth in a population-based series of 490 adult patients with soft tissue sarcoma of the extremity or trunk wall with complete, 4.5 years minimum, follow-up.</p> <p>Results</p> <p>Multivariate analysis showed no major prognostic effect of tumor depth when grade and size were taken into account. The mean size of small tumors was the same whether superficial or deep but the mean size of large and deep-seated tumors were one third larger than that of large but superficial tumors. Tumor depth influenced the prognosis in the subset of high-grade and large tumors. In this subset deep-seated tumors had poorer survival rate than superficial tumors, which could be explained by the larger mean size of the deep-seated tumors.</p> <p>Conclusion</p> <p>Most of the prognostic value of tumor depth in soft tissue sarcomas of the extremity or trunk wall can be explained by the association between tumor size and depth.</p>http://www.biomedcentral.com/1471-2407/3/17prognosissoft tissue sarcomastagingtumor depth |
| spellingShingle | Gustafson Pelle Rydholm Anders Should tumor depth be included in prognostication of soft tissue sarcoma? BMC Cancer prognosis soft tissue sarcoma staging tumor depth |
| title | Should tumor depth be included in prognostication of soft tissue sarcoma? |
| title_full | Should tumor depth be included in prognostication of soft tissue sarcoma? |
| title_fullStr | Should tumor depth be included in prognostication of soft tissue sarcoma? |
| title_full_unstemmed | Should tumor depth be included in prognostication of soft tissue sarcoma? |
| title_short | Should tumor depth be included in prognostication of soft tissue sarcoma? |
| title_sort | should tumor depth be included in prognostication of soft tissue sarcoma |
| topic | prognosis soft tissue sarcoma staging tumor depth |
| url | http://www.biomedcentral.com/1471-2407/3/17 |
| work_keys_str_mv | AT gustafsonpelle shouldtumordepthbeincludedinprognosticationofsofttissuesarcoma AT rydholmanders shouldtumordepthbeincludedinprognosticationofsofttissuesarcoma |