Impact of the Clinical Trials Act on Noncommercial Clinical Research in Japan: An Interrupted Time-series Analysis
Background: The number of new noncommercial clinical studies conducted in Japan declined within the first year of the implementation of the Clinical Trials Act (CTA) on April 1, 2018. This study aimed to examine the impact of the CTA’s enforcement on the number of new noncommercial clinical studies...
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2022-01-01
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| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/32/1/32_JE20210051/_pdf |
| _version_ | 1818976298900389888 |
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| author | Ikuyo Tsutsumi Yusuke Tsutsumi Chikashi Yoshida Takuya Komeno Yuichi Imanaka |
| author_facet | Ikuyo Tsutsumi Yusuke Tsutsumi Chikashi Yoshida Takuya Komeno Yuichi Imanaka |
| author_sort | Ikuyo Tsutsumi |
| collection | DOAJ |
| description | Background: The number of new noncommercial clinical studies conducted in Japan declined within the first year of the implementation of the Clinical Trials Act (CTA) on April 1, 2018. This study aimed to examine the impact of the CTA’s enforcement on the number of new noncommercial clinical studies registered in the Japanese Clinical Trial Registry. Methods: An interrupted time-series design was used in the analysis, which was conducted from April 2015 to March 2019. We collected data for studies registered in the Clinical Trial Registry, managed by the University Hospital Medical Information Network. Results: In total, 35,811 studies were registered; of these, 16,455 fulfilled the eligibility criteria. The difference in the trend of monthly number of new studies after CTA enforcement decreased significantly by 15.0 (95% confidence interval [CI], −18.7 to −11.3), and the level decreased by 40.8 (95% CI, −68.2 to −13.3) studies from the pre-enforcement to the post-enforcement period. Multigroup analyses indicated that the act exerted a significant effect on the trend of new clinical studies, particularly those with smaller sample sizes, interventional study designs, and nonprofit funding sponsors. Conclusions: The number of Japanese noncommercial clinical studies declined significantly following implementation of the CTA. It is necessary to establish a system to promote clinical studies in Japan while ensuring transparency and safety. |
| first_indexed | 2024-12-20T16:09:38Z |
| format | Article |
| id | doaj.art-a666b8d683f14729ac698f3dd760db72 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-12-20T16:09:38Z |
| publishDate | 2022-01-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-a666b8d683f14729ac698f3dd760db722022-12-21T19:34:03ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922022-01-01321273310.2188/jea.JE20210051Impact of the Clinical Trials Act on Noncommercial Clinical Research in Japan: An Interrupted Time-series AnalysisIkuyo Tsutsumi0Yusuke Tsutsumi1Chikashi Yoshida2Takuya Komeno3Yuichi Imanaka4Department of Healthcare Economics and Quality Management, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Emergency Medicine, National Hospital Organization Mito Medical Center, Ibaraki, JapanDepartment of Hematology, National Hospital Organization Mito Medical Center, Ibaraki, JapanDepartment of Hematology, National Hospital Organization Mito Medical Center, Ibaraki, JapanDepartment of Healthcare Economics and Quality Management, Kyoto University Graduate School of Medicine, Kyoto, JapanBackground: The number of new noncommercial clinical studies conducted in Japan declined within the first year of the implementation of the Clinical Trials Act (CTA) on April 1, 2018. This study aimed to examine the impact of the CTA’s enforcement on the number of new noncommercial clinical studies registered in the Japanese Clinical Trial Registry. Methods: An interrupted time-series design was used in the analysis, which was conducted from April 2015 to March 2019. We collected data for studies registered in the Clinical Trial Registry, managed by the University Hospital Medical Information Network. Results: In total, 35,811 studies were registered; of these, 16,455 fulfilled the eligibility criteria. The difference in the trend of monthly number of new studies after CTA enforcement decreased significantly by 15.0 (95% confidence interval [CI], −18.7 to −11.3), and the level decreased by 40.8 (95% CI, −68.2 to −13.3) studies from the pre-enforcement to the post-enforcement period. Multigroup analyses indicated that the act exerted a significant effect on the trend of new clinical studies, particularly those with smaller sample sizes, interventional study designs, and nonprofit funding sponsors. Conclusions: The number of Japanese noncommercial clinical studies declined significantly following implementation of the CTA. It is necessary to establish a system to promote clinical studies in Japan while ensuring transparency and safety.https://www.jstage.jst.go.jp/article/jea/32/1/32_JE20210051/_pdfclinical trials actinterrupted time-series analysisclinical research |
| spellingShingle | Ikuyo Tsutsumi Yusuke Tsutsumi Chikashi Yoshida Takuya Komeno Yuichi Imanaka Impact of the Clinical Trials Act on Noncommercial Clinical Research in Japan: An Interrupted Time-series Analysis Journal of Epidemiology clinical trials act interrupted time-series analysis clinical research |
| title | Impact of the Clinical Trials Act on Noncommercial Clinical Research in Japan: An Interrupted Time-series Analysis |
| title_full | Impact of the Clinical Trials Act on Noncommercial Clinical Research in Japan: An Interrupted Time-series Analysis |
| title_fullStr | Impact of the Clinical Trials Act on Noncommercial Clinical Research in Japan: An Interrupted Time-series Analysis |
| title_full_unstemmed | Impact of the Clinical Trials Act on Noncommercial Clinical Research in Japan: An Interrupted Time-series Analysis |
| title_short | Impact of the Clinical Trials Act on Noncommercial Clinical Research in Japan: An Interrupted Time-series Analysis |
| title_sort | impact of the clinical trials act on noncommercial clinical research in japan an interrupted time series analysis |
| topic | clinical trials act interrupted time-series analysis clinical research |
| url | https://www.jstage.jst.go.jp/article/jea/32/1/32_JE20210051/_pdf |
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