[68Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants
[68Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification 2016 grade III and IV) shows elevated levels of CXCR4 ligand expression in the a...
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| Format: | Article |
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Mashhad University of Medical Sciences
2023-06-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
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| Online Access: | https://aojnmb.mums.ac.ir/article_21342_a86723b220fb4b09eec66528298cf987.pdf |
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| author | Hessamoddin Roustaei Emran Askari Somayeh Barashki Kazem Anvari Ramin Sadeghi Kamran Aryana |
| author_facet | Hessamoddin Roustaei Emran Askari Somayeh Barashki Kazem Anvari Ramin Sadeghi Kamran Aryana |
| author_sort | Hessamoddin Roustaei |
| collection | DOAJ |
| description | [68Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification 2016 grade III and IV) shows elevated levels of CXCR4 ligand expression in the affected tumoral cells. Healthy and non-affected organ cells express low-level CXCR4 ligands density. We performed [68Ga] Ga-Pentixafor (Pars-Cixafor™) PET/CT in a patient with high-grade Glioma (anaplastic oligodendroglioma WHO grade III) with no other documented medical condition and history. In addition to the Pentixafor-avid tumor remnant in the PET/CT images, we observed mild symmetrical bilateral uptake in the fibro glandular tissue of the breasts and moderate CXCR4(Pentixafor) avidity in both adrenal glands without any discernable pathology and abnormal density changes in the CT component of the study. Attention should be paid to the interpreting [68Ga] Ga-Pentixafor PET/CT examination and its normal uptakes and variants. |
| first_indexed | 2024-03-13T07:43:02Z |
| format | Article |
| id | doaj.art-a666eda671df4228b863649909a01889 |
| institution | Directory Open Access Journal |
| issn | 2322-5718 2322-5726 |
| language | English |
| last_indexed | 2024-03-13T07:43:02Z |
| publishDate | 2023-06-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj.art-a666eda671df4228b863649909a018892023-06-03T06:33:47ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262023-06-0111216817010.22038/aojnmb.2022.66223.145821342[68Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variantsHessamoddin Roustaei0Emran Askari1Somayeh Barashki2Kazem Anvari3Ramin Sadeghi4Kamran Aryana5Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranCancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran[68Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification 2016 grade III and IV) shows elevated levels of CXCR4 ligand expression in the affected tumoral cells. Healthy and non-affected organ cells express low-level CXCR4 ligands density. We performed [68Ga] Ga-Pentixafor (Pars-Cixafor™) PET/CT in a patient with high-grade Glioma (anaplastic oligodendroglioma WHO grade III) with no other documented medical condition and history. In addition to the Pentixafor-avid tumor remnant in the PET/CT images, we observed mild symmetrical bilateral uptake in the fibro glandular tissue of the breasts and moderate CXCR4(Pentixafor) avidity in both adrenal glands without any discernable pathology and abnormal density changes in the CT component of the study. Attention should be paid to the interpreting [68Ga] Ga-Pentixafor PET/CT examination and its normal uptakes and variants.https://aojnmb.mums.ac.ir/article_21342_a86723b220fb4b09eec66528298cf987.pdfcxcr4high-grade gliomaadrenalbreastpet/ct |
| spellingShingle | Hessamoddin Roustaei Emran Askari Somayeh Barashki Kazem Anvari Ramin Sadeghi Kamran Aryana [68Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants Asia Oceania Journal of Nuclear Medicine and Biology cxcr4 high-grade glioma adrenal breast pet/ct |
| title | [68Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
| title_full | [68Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
| title_fullStr | [68Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
| title_full_unstemmed | [68Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
| title_short | [68Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants |
| title_sort | 68ga ga pentixafor diffuse bilateral adrenal breast uptake in a patient with high grade glioma a note of caution on normal variants |
| topic | cxcr4 high-grade glioma adrenal breast pet/ct |
| url | https://aojnmb.mums.ac.ir/article_21342_a86723b220fb4b09eec66528298cf987.pdf |
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