Formation of ketoprofen methyl ester artifact in GC–MS analysis of basic drugs in horse urine using alkaline liquid-liquid extraction

Formation of ketoprofen methyl ester artifact in GC–MS analysis of basic drugs in horse urine using alkaline liquid-liquid extraction

This study investigates the unexpected formation of ketoprofen methyl ester (KME) during the routine alkaline liquid–liquid extraction (LLE) process for analyzing basic drugs in horse urine samples using GC–MS analysis. An unidentified peak in the GC–MS chromatogram was observed in certain horse uri...

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Bibliographic Details
Main Authors: Chaksawat Sangawitayakorn, Pirom Chenprakhon, Prapin Wilairat, Rattikan Chantiwas
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Arabian Journal of Chemistry
Subjects:
Artifacts
Ketoprofen methyl ester
Horse urine
Liquid–liquid extraction
GC–MS
Drug analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535224001291

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