Antiacetylcholinesterase Activity of Cyclosporine – A Comparison of Single and Repeated Administration and Effect of 7-Methoxytacrine
The aim of this work is a comparison of single and repeated peroral administration of cyclosporine (CsA) and the interaction of repeated administration of CsA and 7-methoxytacrine (MEOTA) on the activity of acetylcholinesterase (AChE) in the frontal cortex, hippocampus, septum, and basal ganglia in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karolinum Press
2002-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/45/4/0145/ |
| _version_ | 1828495897256787968 |
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| author | Josef Herink Gabriela Krejčová Jiří Bajgar |
| author_facet | Josef Herink Gabriela Krejčová Jiří Bajgar |
| author_sort | Josef Herink |
| collection | DOAJ |
| description | The aim of this work is a comparison of single and repeated peroral administration of cyclosporine (CsA) and the interaction of repeated administration of CsA and 7-methoxytacrine (MEOTA) on the activity of acetylcholinesterase (AChE) in the frontal cortex, hippocampus, septum, and basal ganglia in rats. Both single and repeated administration of CsA diminished the activity of AChE in the frontal cortex, septum and basal ganglia, while the enzyme activity in the hippocampus was diminished only in the case of repeated CsA, as well as repeated CsA + MEOTA administration. Repeated administration of CsA led to a further augmentation of anticholinesterase activity only in the frontal cortex and – in a lesser extent – in the basal ganglia. No augmentation of AChE activity was observed in the hippocampus and septum. |
| first_indexed | 2024-12-11T12:20:25Z |
| format | Article |
| id | doaj.art-a66c157a51ca4ea7ab149d952c4f509a |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-11T12:20:25Z |
| publishDate | 2002-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-a66c157a51ca4ea7ab149d952c4f509a2022-12-22T01:07:33ZengKarolinum PressActa Medica1211-42861805-96942002-01-0145414514710.14712/18059694.2019.71Antiacetylcholinesterase Activity of Cyclosporine – A Comparison of Single and Repeated Administration and Effect of 7-MethoxytacrineJosef Herink0Gabriela Krejčová1Jiří Bajgar2Purkyně Military Medical Academy in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicPurkyně Military Medical Academy in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicPurkyně Military Medical Academy in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicThe aim of this work is a comparison of single and repeated peroral administration of cyclosporine (CsA) and the interaction of repeated administration of CsA and 7-methoxytacrine (MEOTA) on the activity of acetylcholinesterase (AChE) in the frontal cortex, hippocampus, septum, and basal ganglia in rats. Both single and repeated administration of CsA diminished the activity of AChE in the frontal cortex, septum and basal ganglia, while the enzyme activity in the hippocampus was diminished only in the case of repeated CsA, as well as repeated CsA + MEOTA administration. Repeated administration of CsA led to a further augmentation of anticholinesterase activity only in the frontal cortex and – in a lesser extent – in the basal ganglia. No augmentation of AChE activity was observed in the hippocampus and septum.https://actamedica.lfhk.cuni.cz/45/4/0145/AcetylcholinesteraseBrain partsCyclosporine7-MethoxytacrineRat |
| spellingShingle | Josef Herink Gabriela Krejčová Jiří Bajgar Antiacetylcholinesterase Activity of Cyclosporine – A Comparison of Single and Repeated Administration and Effect of 7-Methoxytacrine Acta Medica Acetylcholinesterase Brain parts Cyclosporine 7-Methoxytacrine Rat |
| title | Antiacetylcholinesterase Activity of Cyclosporine – A Comparison of Single and Repeated Administration and Effect of 7-Methoxytacrine |
| title_full | Antiacetylcholinesterase Activity of Cyclosporine – A Comparison of Single and Repeated Administration and Effect of 7-Methoxytacrine |
| title_fullStr | Antiacetylcholinesterase Activity of Cyclosporine – A Comparison of Single and Repeated Administration and Effect of 7-Methoxytacrine |
| title_full_unstemmed | Antiacetylcholinesterase Activity of Cyclosporine – A Comparison of Single and Repeated Administration and Effect of 7-Methoxytacrine |
| title_short | Antiacetylcholinesterase Activity of Cyclosporine – A Comparison of Single and Repeated Administration and Effect of 7-Methoxytacrine |
| title_sort | antiacetylcholinesterase activity of cyclosporine a comparison of single and repeated administration and effect of 7 methoxytacrine |
| topic | Acetylcholinesterase Brain parts Cyclosporine 7-Methoxytacrine Rat |
| url | https://actamedica.lfhk.cuni.cz/45/4/0145/ |
| work_keys_str_mv | AT josefherink antiacetylcholinesteraseactivityofcyclosporineacomparisonofsingleandrepeatedadministrationandeffectof7methoxytacrine AT gabrielakrejcova antiacetylcholinesteraseactivityofcyclosporineacomparisonofsingleandrepeatedadministrationandeffectof7methoxytacrine AT jiribajgar antiacetylcholinesteraseactivityofcyclosporineacomparisonofsingleandrepeatedadministrationandeffectof7methoxytacrine |