Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis [version 2; referees: 2 approved]
Aims: To investigate the association between the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) polymorphism rs 2236225 (c.1958G>A) and susceptibility to non-syndromic cleft of the lip and/or palate (NSCL/P). Methods: An extensive literature review has been conducted using PubMed, Web of Scie...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2016-01-01
|
| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/4-142/v2 |
| _version_ | 1828836727372906496 |
|---|---|
| author | Huaxiang Zhao Jieni Zhang Mengqi Zhang Feng Deng Leilei Zheng Hui Zheng Feng Chen Jiuxiang Lin |
| author_facet | Huaxiang Zhao Jieni Zhang Mengqi Zhang Feng Deng Leilei Zheng Hui Zheng Feng Chen Jiuxiang Lin |
| author_sort | Huaxiang Zhao |
| collection | DOAJ |
| description | Aims: To investigate the association between the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) polymorphism rs 2236225 (c.1958G>A) and susceptibility to non-syndromic cleft of the lip and/or palate (NSCL/P). Methods: An extensive literature review has been conducted using PubMed, Web of Science, Cochrane Library, Google Scholar, the China National Knowledge Infrastructure (CNKI), and Wanfang Database for eligible researches. The terms for searching were “cleft lip OR cleft palate OR CLP OR CL/P OR oral facial cleft OR OFC” AND “methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 OR methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase OR MTHFD1 OR MTHFD”. Two independent researchers screened, evaluated and extracted the data of included studies. The pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated by random effects model under five gene models. Subgroup, sensitivity analysis and publication bias were also assessed. Results: Ten case-control studies have been included in the systematic review and eight studies have been considered for the meta-analysis. Overall, the MTHFD1 polymorphism rs2236225 and the risk of NSCL/P showed pooled OR (95% CI) of 1.02 (0.86-1.21) under allelic model. A higher degree of heterogeneity was observed in Asian countries (I2 = 75.6%) compared to non-Asian countries (I2 = 48.9%). Similar consequence appeared in the subgroup of children (I2 = 78.6%) compared with that of mothers (I2 = 0.0%). There was no significant difference in the publication bias by the Begg’s funnel plot (P = 0.711) and Egger’s regression test (P = 0.746). Conclusion: Our assessment suggested there was no significant association between the MTHFD1 polymorphism rs 2236225 (c.1958G>A) and the susceptibility to NSCL/P. Further investigations using a large sample size and a more advanced technique should be adopted to reach a more precise conclusion in the future. |
| first_indexed | 2024-12-12T18:26:37Z |
| format | Article |
| id | doaj.art-a66caa63e6964dab866b4b180e5579ec |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-12T18:26:37Z |
| publishDate | 2016-01-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-a66caa63e6964dab866b4b180e5579ec2022-12-22T00:16:01ZengF1000 Research LtdF1000Research2046-14022016-01-01410.12688/f1000research.6425.27371Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis [version 2; referees: 2 approved]Huaxiang Zhao0Jieni Zhang1Mengqi Zhang2Feng Deng3Leilei Zheng4Hui Zheng5Feng Chen6Jiuxiang Lin7Department of Orthodontics, Peking University School and Hospital of Stomatology, Peking, 100081, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Peking, 100081, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Peking, 100081, ChinaBybo Dental Group, Beijing, 100062, ChinaDepartment of Orthodontics, Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing, 401147, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Peking, 100081, ChinaLaboratory Center, Peking University School and Hospital of Stomatology, Peking, 100081, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Peking, 100081, ChinaAims: To investigate the association between the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) polymorphism rs 2236225 (c.1958G>A) and susceptibility to non-syndromic cleft of the lip and/or palate (NSCL/P). Methods: An extensive literature review has been conducted using PubMed, Web of Science, Cochrane Library, Google Scholar, the China National Knowledge Infrastructure (CNKI), and Wanfang Database for eligible researches. The terms for searching were “cleft lip OR cleft palate OR CLP OR CL/P OR oral facial cleft OR OFC” AND “methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 OR methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase OR MTHFD1 OR MTHFD”. Two independent researchers screened, evaluated and extracted the data of included studies. The pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated by random effects model under five gene models. Subgroup, sensitivity analysis and publication bias were also assessed. Results: Ten case-control studies have been included in the systematic review and eight studies have been considered for the meta-analysis. Overall, the MTHFD1 polymorphism rs2236225 and the risk of NSCL/P showed pooled OR (95% CI) of 1.02 (0.86-1.21) under allelic model. A higher degree of heterogeneity was observed in Asian countries (I2 = 75.6%) compared to non-Asian countries (I2 = 48.9%). Similar consequence appeared in the subgroup of children (I2 = 78.6%) compared with that of mothers (I2 = 0.0%). There was no significant difference in the publication bias by the Begg’s funnel plot (P = 0.711) and Egger’s regression test (P = 0.746). Conclusion: Our assessment suggested there was no significant association between the MTHFD1 polymorphism rs 2236225 (c.1958G>A) and the susceptibility to NSCL/P. Further investigations using a large sample size and a more advanced technique should be adopted to reach a more precise conclusion in the future.http://f1000research.com/articles/4-142/v2Developmental Molecular MechanismsGenomics |
| spellingShingle | Huaxiang Zhao Jieni Zhang Mengqi Zhang Feng Deng Leilei Zheng Hui Zheng Feng Chen Jiuxiang Lin Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis [version 2; referees: 2 approved] F1000Research Developmental Molecular Mechanisms Genomics |
| title | Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis [version 2; referees: 2 approved] |
| title_full | Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis [version 2; referees: 2 approved] |
| title_fullStr | Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis [version 2; referees: 2 approved] |
| title_full_unstemmed | Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis [version 2; referees: 2 approved] |
| title_short | Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis [version 2; referees: 2 approved] |
| title_sort | is mthfd1 polymorphism rs 2236225 c 1958g a associated with the susceptibility of nscl p a systematic review and meta analysis version 2 referees 2 approved |
| topic | Developmental Molecular Mechanisms Genomics |
| url | http://f1000research.com/articles/4-142/v2 |
| work_keys_str_mv | AT huaxiangzhao ismthfd1polymorphismrs2236225c1958gaassociatedwiththesusceptibilityofnsclpasystematicreviewandmetaanalysisversion2referees2approved AT jienizhang ismthfd1polymorphismrs2236225c1958gaassociatedwiththesusceptibilityofnsclpasystematicreviewandmetaanalysisversion2referees2approved AT mengqizhang ismthfd1polymorphismrs2236225c1958gaassociatedwiththesusceptibilityofnsclpasystematicreviewandmetaanalysisversion2referees2approved AT fengdeng ismthfd1polymorphismrs2236225c1958gaassociatedwiththesusceptibilityofnsclpasystematicreviewandmetaanalysisversion2referees2approved AT leileizheng ismthfd1polymorphismrs2236225c1958gaassociatedwiththesusceptibilityofnsclpasystematicreviewandmetaanalysisversion2referees2approved AT huizheng ismthfd1polymorphismrs2236225c1958gaassociatedwiththesusceptibilityofnsclpasystematicreviewandmetaanalysisversion2referees2approved AT fengchen ismthfd1polymorphismrs2236225c1958gaassociatedwiththesusceptibilityofnsclpasystematicreviewandmetaanalysisversion2referees2approved AT jiuxianglin ismthfd1polymorphismrs2236225c1958gaassociatedwiththesusceptibilityofnsclpasystematicreviewandmetaanalysisversion2referees2approved |